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1. Introduction
2. Talk outline
3. The human intestinal tract
4. Location of Paneth cells
5. Paneth cells - background (1)
6. Paneth cells - background (2)
7. Paneth cells - ultrastructure
8. Lysozyme
9. Paneth cell defensins
10. Matrilysin processes PC-derived defensins
11. Defensins protect against Salmonella infection (1)
12. Defensins protect against Salmonella infection (2)
13. PC secrete defensins in response to bacteria
14. Symbiotic bacteria induce RegIII in PC
15. Paneth cells express an antibacterial sPLA2
16. Intestinal secretory PLA2
17. Antimicrobial gene expression in human PC
18. Paneth cells - zinc
19. Paneth cells - IgA
20. Ablation of Paneth cells
21. Gene expression in Paneth cells
22. TNFalpha gene expression in murine PC
23. TNFalpha is expressed in PC in Crohn's disease
24. TNFdeltaARE mice over-express TNFalpha
25. TNFdeltaARE mice develop Crohn's-like ileitis
26. TNF-induced lethal shock - mediated by IL-17
27. IL-23 localized to PC in ankylosing spondylitis
28. Local CSF1 is required for PC differentiation
29. IL-9 mediates PC differentiation
30. Immune cells mediate antimicrobial effect via PC
31. PC involvement in IBD pathogenesis
32. Ulcerative colitis and Crohn's disease = IBD
33. Normal and Crohn's affected intestine
34. NOD2 gene and Crohn's disease
35. NOD2 mutations are associated with ileal Crohn's
36. NOD2 RNA is constitutively expressed in PC
37. NOD2 mRNA is expressed in microdissected PC
38. NOD2 protein is localized to PC cytoplasm
39. NOD2 levels are similar in monocytes and PC
40. NOD2 mRNA in monocytes vs. macrophages (1)
41. NOD2 mRNA in monocytes vs. macrophages (2)
42. Paneth cells secretion assay
43. Control of Paneth cell secretion
44. PC are highly responsive to MDP
45. Imbalance of enteric bacteria cause IBD
46. Crohn's disease: a defensin deficiency syndrome?
47. Defensin expression regulated by inflammation
48. Effect of NOD2 mutations (1)
49. Effect of NOD2 mutations (2)
50. APC and beta-catenin promote differentiation of PC
51. Beta-catenin and TCF4 regulate alpha-defensins
52. SOX-9 is required for differentiation of PC
53. Beta-catenin signalling
54. PPAR genes regulate the differentiation of PC
55. ATG16L, IRGM associated with Crohn's disease
56. ATG16L mutation affects the morphology of PC
57. PC in immunity and inflammation
58. Summary

Topics Covered

• Position and structure of Paneth cells
• Produce diverse protein products
• Ultrastructure
• Lysozyme
• Paneth cell defensins
• Salmonella infection
• Antimicrobial function
• Zinc
• IgA
• Effects of lineage ablation
• TNFalfa
• Expression of immune-related genes
• Potential role in human disease
• Are Paneth cells involved in the pathogenesis of IBD?
• Ulcerative colitis and Crohn's disease
• The NOD2 gene
• Control of Paneth cell secretion
• Paneth cells highly responsive to MPD
• Defensin expression
• Paneth cell morphology and gene expression are altered in IBD

Links

Series:

• Innate Immunity

Categories:

• Clinical Practice
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Keshav, S. (2009, July 8). Paneth cells in innate immunity and inflammatory bowel disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/QCQK5935.
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Publication History

• Published on July 8, 2009

Financial Disclosures

• Prof. Satish Keshav has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.