• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. NLRs and TLRs mediate elimination of pathogens
3. The NOD-like receptor (NLR) family
4. NLR mutations and susceptibility to diseases
5. Signal transduction pathways involving NLRs
6. Cell wall molecules recognized by Nod1/2
7. Internalization of Nod1/2 activators
8. NLR oligomerization induces downstream events
9. Nod1/2 signaling pathway
10. Function of Nod1 at epithelial barriers
11. Nod2
12. MDP internalization by macrophages
13. MDP localizes to acidic vesicles in macrophages
14. Crohn's disease (CD)
15. Genetic variants of Nod2 associated with CD
16. Recognition of MDP by CD-associated mutants
17. NF-kB activation mediated by MDP requires Nod2
18. MDP induced IL-8 response
19. Four mechanisms for explaining CD susceptibility
20. Requirements for TLR and MDP synergism
21. TLR signaling is impaired by Nod2 mutations
22. Nod2 mutations are associated with ileal disease
23. Expression of Nod2 protein in Paneth cells
24. Putative in vivo roles for Paneth cells
25. Critical role for Nod2 in Listeria infection
26. Reduced Paneth cell defensins in ileal CD
27. Host defense: a double edged sword
28. TLR tolerization
29. Lack of cross-tolerization
30. NF-kB, MAPK in LPS, MDP-treated macrophages
31. Gene microarray analysis
32. Nod1/2 are critical for responses to Listeria
33. Listeria clearance from the liver
34. IL6 secretion and survival in the absence of Nod1/2
35. Role of Nod1/2 in tolerized macrophages
36. Model for the role of Nod2 in Crohn's disease
37. Caspase 1 activation
38. Ipaf and TLR in response to pathogens
39. Treatment of MWS patients with IL1ra
40. WT and Nlrp3-/- macrophage response
41. Alternative: the 'cytosolic sensing' model
42. The role of pannexin-1 in inflammasome activation
43. Relocalization of MDP in response to ATP
44. Re-localization of MDP is regulated by pannexin-1
45. Summary of caspase-1 activation model
46. Acknowledgement

Topics Covered

• Signaling pathways involved in the recognition of microbes
• Nod-like receptors (NLRs)
• Signaling pathways activated by NLRs
• Microbial components sensed by NLRs
• Nod1 and Nod2 signaling pathways
• Nod2 and Crohn's disease
• Interactions between TLRs and NLRs
• The inflammasome
• NLRs and the Inflammasome

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 30, 2009

Financial Disclosures

• Prof. Gabriel Nunez has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.