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1. Introduction
2. NLRs and TLRs mediate elimination of pathogens
3. The NOD-like receptor (NLR) family
4. NLR mutations and susceptibility to diseases
5. Signal transduction pathways involving NLRs
6. Cell wall molecules recognized by Nod1/2
7. Internalization of Nod1/2 activators
8. NLR oligomerization induces downstream events
9. Nod1/2 signaling pathway
10. Function of Nod1 at epithelial barriers
11. Nod2
12. MDP internalization by macrophages
13. MDP localizes to acidic vesicles in macrophages
14. Crohn's disease (CD)
15. Genetic variants of Nod2 associated with CD
16. Recognition of MDP by CD-associated mutants
17. NF-kB activation mediated by MDP requires Nod2
18. MDP induced IL-8 response
19. Four mechanisms for explaining CD susceptibility
20. Requirements for TLR and MDP synergism
21. TLR signaling is impaired by Nod2 mutations
22. Nod2 mutations are associated with ileal disease
23. Expression of Nod2 protein in Paneth cells
24. Putative in vivo roles for Paneth cells
25. Critical role for Nod2 in Listeria infection
26. Reduced Paneth cell defensins in ileal CD
27. Host defense: a double edged sword
28. TLR tolerization
29. Lack of cross-tolerization
30. NF-kB, MAPK in LPS, MDP-treated macrophages
31. Gene microarray analysis
32. Nod1/2 are critical for responses to Listeria
33. Listeria clearance from the liver
34. IL6 secretion and survival in the absence of Nod1/2
35. Role of Nod1/2 in tolerized macrophages
36. Model for the role of Nod2 in Crohn's disease
37. Caspase 1 activation
38. Ipaf and TLR in response to pathogens
39. Treatment of MWS patients with IL1ra
40. WT and Nlrp3-/- macrophage response
41. Alternative: the 'cytosolic sensing' model
42. The role of pannexin-1 in inflammasome activation
43. Relocalization of MDP in response to ATP
44. Re-localization of MDP is regulated by pannexin-1
45. Summary of caspase-1 activation model
46. Acknowledgement

Topics Covered

• Signaling pathways involved in the recognition of microbes
• Nod-like receptors (NLRs)
• Signaling pathways activated by NLRs
• Microbial components sensed by NLRs
• Nod1 and Nod2 signaling pathways
• Nod2 and Crohn's disease
• Interactions between TLRs and NLRs
• The inflammasome
• NLRs and the Inflammasome

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Nunez, G. (2009, June 30). NOD-like receptors in innate immunity and inflammatory disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/TEUW7521.
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Publication History

• Published on June 30, 2009

Financial Disclosures

• Prof. Gabriel Nunez has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.