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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
-
42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
-
51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
-
39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Challenges to lung
- Innate host defense of the lung
- Immune protection in the lung pre- and postnatal
- Stages of the developing lung
- Morphogenetic changes in the developing lung
- Regulation and differentiation in the developing lung
- Diversity of lung epithelial cell
- Type 2 epithelial cells
- Surfactant homeostasis and host defense
- Surfactant composition
- SP-A
- SP-D
- Functions of SP-A and SP-D
- SP-B and SP-C
- TTF-1 regulates the expression of surfactant genes
- TTF-1 functions
- TTF-1 PM (phosphorylation mutant)
- Genes differentially expressed in TTF-1-PM
- Groups of genes regulated by TTF-2
- TTF-1 - summary
- Respiratory distress syndrome in Foxa2 KO mice
- Groups of genes regulated by Foxa2
- Genetic networks- Titf-1, Cebp-alpha and Foxa2
- Transcriptional networks and perinatal adaptation
- Diseases of alveolar homeostasis
- Mutations in surfactant synthesis genes
- The alveolar macrophage
- Pulmonary alveolar proteinosis
- Pathology of GM-CSF KO mice and human PAP
- GM-CSF deficiency causes PAP
- GM-CSF receptor signaling
- Metabolism of SP-A by macrophages
- Alveolar macrophage cell lines
- The importance of GM-CSF
- Anti-GM-CSF autoantibodies
- GM-CSF and surfactant metabolism
- Elimination of GM-CSF activity in PAP
- Potential therapy of alveolar proteinosis
- Therapeutic efficacy of GM-CSF in PAP
- Summary
Topics Covered
- Innate host defense of the lung
- Stages of the developing lung
- Diversity of airway epithelial cell types
- Alveolar host defense
- Surfactant composition
- Respiratory distress syndrome
- Genetic networks
- Transcriptional networks and perinatal adaptation
- Diseases of alveolar homeostasis
- Histopathology of surfactant abnormalities
- Pulmonary alveolar proteinosis
- Alveolar macrophage cell lines
- GM-CSF
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Whitsett, J. (2009, May 31). Innate immunity of the lung and adaptation to air breathing at birth [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/IFZH3148.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Jeffrey Whitsett has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
