Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Challenges to lung
3. Innate host defense of the lung
4. Immune protection in the lung pre- and postnatal
5. Stages of the developing lung
6. Morphogenetic changes in the developing lung
7. Regulation and differentiation in the developing lung
8. Diversity of lung epithelial cell
9. Type 2 epithelial cells
10. Surfactant homeostasis and host defense
11. Surfactant composition
12. SP-A
13. SP-D
14. Functions of SP-A and SP-D
15. SP-B and SP-C
16. TTF-1 regulates the expression of surfactant genes
17. TTF-1 functions
18. TTF-1 PM (phosphorylation mutant)
19. Genes differentially expressed in TTF-1-PM
20. Groups of genes regulated by TTF-2
21. TTF-1 - summary
22. Respiratory distress syndrome in Foxa2 KO mice
23. Groups of genes regulated by Foxa2
24. Genetic networks- Titf-1, Cebp-alpha and Foxa2
25. Transcriptional networks and perinatal adaptation
26. Diseases of alveolar homeostasis
27. Mutations in surfactant synthesis genes
28. The alveolar macrophage
29. Pulmonary alveolar proteinosis
30. Pathology of GM-CSF KO mice and human PAP
31. GM-CSF deficiency causes PAP
32. GM-CSF receptor signaling
33. Metabolism of SP-A by macrophages
34. Alveolar macrophage cell lines
35. The importance of GM-CSF
36. Anti-GM-CSF autoantibodies
37. GM-CSF and surfactant metabolism
38. Elimination of GM-CSF activity in PAP
39. Potential therapy of alveolar proteinosis
40. Therapeutic efficacy of GM-CSF in PAP
41. Summary

Topics Covered

• Innate host defense of the lung
• Stages of the developing lung
• Diversity of airway epithelial cell types
• Alveolar host defense
• Surfactant composition
• Respiratory distress syndrome
• Genetic networks
• Transcriptional networks and perinatal adaptation
• Diseases of alveolar homeostasis
• Histopathology of surfactant abnormalities
• Pulmonary alveolar proteinosis
• Alveolar macrophage cell lines
• GM-CSF

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Whitsett, J. (2009, May 31). Innate immunity of the lung and adaptation to air breathing at birth [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/IFZH3148.
Export Citation (RIS)

Publication History

• Published on May 31, 2009
• Archived on February 25, 2021

Financial Disclosures

• Prof. Jeffrey Whitsett has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.