• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Outline
3. What is innate immunity? (1)
4. Critical role of innate immunity in children (1)
5. Critical role of innate immunity in children (2)
6. Elements of the immune system (1)
7. Elements of the immune system (2)
8. Defect in nonspecific immunity
9. Defect in adaptive immunity
10. Elements of the innate immune system
11. The cellular and humoral arms
12. Cellular elements for innate defense
13. Functions of the phagocytic system
14. Humoral arm of the innate immune system
15. Complement in innate defense
16. Complement cascade
17. Opsonization
18. Complement-mediated lysis
19. Inflammation: a fine balance
20. The canonical NFkappa-B pathway
21. Innate immunity -- sensing and signaling
22. NF-kappa-B structure
23. Defects that cause immunodeficiency in children
24. Inflammatory dysfunction
25. Child with IRAK-4 deficiency
26. IRAK-4 deficient macrophage response to LPS
27. Phenotype of IRAK-4 deficiency
28. STAT-1 deficiency
29. UNC-93B deficiency
30. IL-12 / interferon-gamma axis defect
31. Phagocytes in innate defense
32. Phagocytosis
33. Leukocyte adhesion deficiency
34. Lesions in LAD patient
35. LAD patient at one year of age
36. Chronic granulomatous disease
37. Molecular defects in CGD
38. Manifestations of CGD
39. Patient with mild CGD
40. Patient with severe CGD
41. Genetic polymorphisms and the innate immunity
42. Therapeutic approaches
43. Strategies to enhance/arm innate immune system
44. Conclusions

Topics Covered

• Host defense in children is composed of non-specific, innate and adaptive limbs
• Innate immunity is critical in defense against infection in children
• Innate immunity is composed of cellular and humoral elements
• Defects in innate immunity provide powerful insights into the importance of this limb of the host defense system in defense against infection
• New therapeutic strategies are being developed based upon novel observations of innate immunodeficiencies in children

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. David Speert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.