• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Talk outline
3. Defining cationic peptides
4. Cationic peptides in innate immunity
5. The Cathelicidins
6. The Defensins
7. Antibiotic activity in vitro (1)
8. Cationic peptides have a broad spectrum activity
9. Antibiotic activity in vitro (2)
10. Mechanism of action of cationic peptides
11. Multiple mechanisms of killing microbes
12. Physiological conditions and antibiotic activity(1)
13. Physiological conditions and antibiotic activity(2)
14. Bacterial evasion mechanism
15. Bacterial evasion - the example of Shigella flexneri
16. In vivo data regarding antibiotic activity
17. Antimicrobial activity depends upon leukocytes
18. Cationic peptides as immunomodulators
19. Antimicrobial or host defence peptides?
20. Are there receptors for defensins?
21. CCR6 and defensin mediated chemotaxis
22. Do the defensins function via the TLRs?
23. Are there receptors for other CAMPs?
24. Do the cathelicidins have dedicated receptors?
25. Role in human disease - Mtb infection (1)
26. Role in human disease - Mtb infection (2)
27. Role in skin diseases (1)
28. Role in skin diseases (2)
29. Pro or anti inflammatory? LPS & IL-6
30. Pro or anti inflammatory? IL-8
31. LL37 and leukocyte accumulation theories (1)
32. LL37 and leukocyte accumulation theories (2)
33. LPS vs. IL-1beta stimulation
34. Prevalence of Superbugs
35. Cationic peptides as potential drug targets (1)
36. Cationic peptides as potential drug targets (2)
37. Cationic peptides as potential drug targets (3)
38. Spot synthesis of peptides using a pipetting robot
39. Isolation of active 8-amino acid peptides
40. Future directions

Topics Covered

• Cationic peptides: a definition
• The cathelicidins
• The defensins
• Antibiotic activity in vitro
• Antibiotic activity: mechanisms of action
• Antibiotic activity under physiologic conditions and in vivo
• Bacterial evasion
• Cationic peptides as immunomodulators
• Are interactions with host cells receptor mediated or are there other mechanisms of action?
• Role in human infectious disease, e.g. Mycobacterium tuberculosis infection
• Role in human inflammatory disease, e.g. psoriasis
• gla-3- Are cationic peptides pro- or anti-inflammatory?
• Cationic peptides as drug targets

Links

Series:

• Innate Immunity

Categories:

• Biochemistry
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 30, 2009

Financial Disclosures

• Dr. Dawn Bowdish has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.