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- Models of Investigation
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1. Antifungal innate immunity in C. elegans
- Dr. Jonathan Ewbank
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2. The anti-microbial defense of Drosophila: a paradigm for innate immunity
- Prof. Jules Hoffmann
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3. Phagocytosis in the fruit fly, Drosophila melanogaster
- Dr. Lynda Stuart
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4. Innate immune sensing and response
- Prof. Bruce Beutler
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5. Macrophages and systems biology
- Prof. David Hume
- Cell Types and Recruitment
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6. Leukocyte recruitment in vivo
- Prof. Paul Kubes
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8. Eosinophils
- Prof. Tim Williams
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9. Dendritic cells: linking innate to different forms of adaptive immunity
- Prof. Ralph Steinman
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11. Innate-like lymphocytes 1
- Prof. Adrian Hayday
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12. Innate-like lymphocytes 2
- Prof. Adrian Hayday
- Recognition and Signaling
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13. Colony stimulating factor-1 regulation of macrophages in development and disease
- Prof. E. Richard Stanley
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14. Fc receptors: linking innate and acquired immunity
- Prof. Ken G C Smith
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15. Phagocytosis
- Prof. Joel Swanson
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16. Clearance of apoptotic cells and the control of inflammation
- Prof. Sir John Savill
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17. Signaling by innate immune receptors
- Prof. Michael Karin
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18. Nuclear receptors at the crossroads of inflammation and atherosclerosis
- Prof. Christopher Glass
- Modulation of Effector Responses
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19. Humoral innate immunity and the acute phase response 1
- Prof. Alberto Mantovani
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20. Humoral innate immunity and the acute phase response 2
- Prof. Alberto Mantovani
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21. Cytokines regulating the innate response
- Prof. Anne O’Garra
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22. Arginase and nitric oxide
- Dr. Peter Murray
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23. Novel lipid mediators in resolution of inflammation
- Prof. Charles Serhan
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25. Cationic peptides in innate immunity
- Dr. Dawn Bowdish
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26. Iron metabolism and innate immunity
- Prof. Tomas Ganz
- Pathogen-Host Interactions
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27. Innate recognition of viruses
- Prof. Caetano Reis e Sousa
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28. Type I interferons in innate immunity to viral infections
- Prof. Christine Biron
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29. HIV-1 and immunopathogenesis: innate immunity
- Prof. Luis Montaner
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30. Understanding and combating tuberculosis
- Prof. David Russell
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32. Innate immunity and malaria
- Prof. Douglas Golenbock
- Health and Disease
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33. Innate immunity in children
- Prof. David Speert
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34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis
- Prof. Sir Ravinder Maini
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35. NOD-like receptors in innate immunity and inflammatory disease
- Prof. Gabriel Nunez
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36. Paneth cells in innate immunity and inflammatory bowel disease
- Prof. Satish Keshav
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37. Innate immunity in the brain in health and disease
- Prof. V. Hugh Perry
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38. The fate of monocytes in atherosclerosis
- Prof. Gwendolyn Randolph
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39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis
- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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40. Monocyte/macrophages in innate immunity
- Prof. Emeritus Siamon Gordon
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41. Innate immunity in C. elegans
- Dr. Jonathan Ewbank
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43. NLR genes: infection, inflammation and vaccines
- Prof. Jenny Ting
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44. Manipulation of innate immune response: lessons from shigella
- Prof. Philippe Sansonetti
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45. Innate immunity of the lung and adaptation to air breathing at birth
- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Talk outline
- Defining cationic peptides
- Cationic peptides in innate immunity
- The Cathelicidins
- The Defensins
- Antibiotic activity in vitro (1)
- Cationic peptides have a broad spectrum activity
- Antibiotic activity in vitro (2)
- Mechanism of action of cationic peptides
- Multiple mechanisms of killing microbes
- Physiological conditions and antibiotic activity(1)
- Physiological conditions and antibiotic activity(2)
- Bacterial evasion mechanism
- Bacterial evasion - the example of Shigella flexneri
- In vivo data regarding antibiotic activity
- Antimicrobial activity depends upon leukocytes
- Cationic peptides as immunomodulators
- Antimicrobial or host defence peptides?
- Are there receptors for defensins?
- CCR6 and defensin mediated chemotaxis
- Do the defensins function via the TLRs?
- Are there receptors for other CAMPs?
- Do the cathelicidins have dedicated receptors?
- Role in human disease - Mtb infection (1)
- Role in human disease - Mtb infection (2)
- Role in skin diseases (1)
- Role in skin diseases (2)
- Pro or anti inflammatory? LPS & IL-6
- Pro or anti inflammatory? IL-8
- LL37 and leukocyte accumulation theories (1)
- LL37 and leukocyte accumulation theories (2)
- LPS vs. IL-1beta stimulation
- Prevalence of Superbugs
- Cationic peptides as potential drug targets (1)
- Cationic peptides as potential drug targets (2)
- Cationic peptides as potential drug targets (3)
- Spot synthesis of peptides using a pipetting robot
- Isolation of active 8-amino acid peptides
- Future directions
Topics Covered
- Cationic peptides: a definition
- The cathelicidins
- The defensins
- Antibiotic activity in vitro
- Antibiotic activity: mechanisms of action
- Antibiotic activity under physiologic conditions and in vivo
- Bacterial evasion
- Cationic peptides as immunomodulators
- Are interactions with host cells receptor mediated or are there other mechanisms of action?
- Role in human infectious disease, e.g. Mycobacterium tuberculosis infection
- Role in human inflammatory disease, e.g. psoriasis
- gla-3- Are cationic peptides pro- or anti-inflammatory?
- Cationic peptides as drug targets
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Bowdish, D. (2009, June 30). Cationic peptides in innate immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 11, 2024, from https://doi.org/10.69645/HSHM8408.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Dawn Bowdish has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.