Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Talk outline
3. Defining cationic peptides
4. Cationic peptides in innate immunity
5. The Cathelicidins
6. The Defensins
7. Antibiotic activity in vitro (1)
8. Cationic peptides have a broad spectrum activity
9. Antibiotic activity in vitro (2)
10. Mechanism of action of cationic peptides
11. Multiple mechanisms of killing microbes
12. Physiological conditions and antibiotic activity(1)
13. Physiological conditions and antibiotic activity(2)
14. Bacterial evasion mechanism
15. Bacterial evasion - the example of Shigella flexneri
16. In vivo data regarding antibiotic activity
17. Antimicrobial activity depends upon leukocytes
18. Cationic peptides as immunomodulators
19. Antimicrobial or host defence peptides?
20. Are there receptors for defensins?
21. CCR6 and defensin mediated chemotaxis
22. Do the defensins function via the TLRs?
23. Are there receptors for other CAMPs?
24. Do the cathelicidins have dedicated receptors?
25. Role in human disease - Mtb infection (1)
26. Role in human disease - Mtb infection (2)
27. Role in skin diseases (1)
28. Role in skin diseases (2)
29. Pro or anti inflammatory? LPS & IL-6
30. Pro or anti inflammatory? IL-8
31. LL37 and leukocyte accumulation theories (1)
32. LL37 and leukocyte accumulation theories (2)
33. LPS vs. IL-1beta stimulation
34. Prevalence of Superbugs
35. Cationic peptides as potential drug targets (1)
36. Cationic peptides as potential drug targets (2)
37. Cationic peptides as potential drug targets (3)
38. Spot synthesis of peptides using a pipetting robot
39. Isolation of active 8-amino acid peptides
40. Future directions

Topics Covered

• Cationic peptides: a definition
• The cathelicidins
• The defensins
• Antibiotic activity in vitro
• Antibiotic activity: mechanisms of action
• Antibiotic activity under physiologic conditions and in vivo
• Bacterial evasion
• Cationic peptides as immunomodulators
• Are interactions with host cells receptor mediated or are there other mechanisms of action?
• Role in human infectious disease, e.g. Mycobacterium tuberculosis infection
• Role in human inflammatory disease, e.g. psoriasis
• gla-3- Are cationic peptides pro- or anti-inflammatory?
• Cationic peptides as drug targets

Links

Series:

• Innate Immunity

Categories:

• Biochemistry
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 30, 2009

Financial Disclosures

• Dr. Dawn Bowdish has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.