• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Lipid mediators
3. Resolution of acute inflammation
4. Schematic and histological sequence of events
5. Glossary: from PUFA precursors to lipid mediators
6. "Classic" lipoxin-generating pathways
7. Lipoxins and ATL in resolution of inflammation
8. Lipoxins counter-regulate signs of inflammation
9. Production of 15-epi-lipoxins
10. Rapid screening: fast pace to stable analogs
11. 15-(R/S)-methyl LXA4 analog
12. LX and ATL deficiencies in human disease
13. From acute phase to resolution phase
14. Outcome of inflammation: complete resolution
15. Murine dorsal air pouch
16. LC-MS-MS based profiling of lipid mediators
17. LC-MS-MS results: 18R-HEPE
18. Resolvin E1 stops PMN infiltration
19. Biosynthesis of resolvin E1
20. Identification of novel lipid mediators
21. RvE1 in human plasma: mediator lipidomics
22. Resolvins: actions of E series resolvins
23. Resolvin E1: stereospecific total organic synthesis
24. Localized aggressive periodontitis (LAP)
25. Rabbit model for LAP
26. RvE1 protects from inflammatory bone loss
27. Receptor screening for counter-regulatory signals
28. Specific GPCRs for resolvin E1 actions
29. RvE1 acts via two distinct leukocyte GPCRs
30. RvE1 transformation
31. 19-para-fluoro-phenoxyl RvE1
32. DHA precursor to resolvins and protectins
33. Resolvins: actions of D series
34. RvD1 and ATRvD1: human PMN transmigration
35. Resolvins E and D series reduce murine peritonitis
36. Protectins: DHA-derived 17S-series
37. Biosynthesis of protectin D1/ neuroprotectin D1
38. PD1 stops leukocyte infiltration
39. Temporal-differential analyses of resolution
40. Resolution in quantitative terms
41. Upregulation of CCR5 during resolution
42. Resolvins and protectins in humans - summary
43. Resolvins and PD1 identified in murine kidney
44. PD1 and RvD1
45. Activity scores of mice treated with PD1 or RvDs
46. Discovery of a deficiency disease in rats
47. Normal vs. curled tail
48. Summation: some key points to remember
49. Resolvins and known pharmacological agents
50. Resolvins & protectins- summary
51. NIDCR
52. Laboratory of professor Charles N. Serhan

Topics Covered

• Complete resolution of the acute inflammatory response and its return to homeostasis is essential
• Efforts to identify and characterize the cellular and molecular mechanisms that govern resolution of self-limited inflammation
• Systems approach with temporal analysis of the evolving inflammatory exudates using unbiased mediator lipidomics/informatics, proteomics, and cellular traffic with murine resolving exudates
• Novel endogenous pathways of local acting mediators that are dual acting, and that are both anti-inflammatory and pro-resolving
• Biosynthesis and actions of "resolvins" and "protectins"
• E-series resolvins and D-series resolvins
• Actions of neuroprotectin D-1
• Biosynthesis of aspirin-triggered lipid mediators and their impact in regulating acute inflammatory responses
• The resolution of acute inflammation is an active process that can be accelerated

Links

Series:

• Innate Immunity

Categories:

• Biochemistry
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009
• Reviewed on May 1, 2020

Financial Disclosures

• Prof. Charles Serhan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.