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1. Introduction
2. Lipid mediators
3. Resolution of acute inflammation
4. Schematic and histological sequence of events
5. Glossary: from PUFA precursors to lipid mediators
6. "Classic" lipoxin-generating pathways
7. Lipoxins and ATL in resolution of inflammation
8. Lipoxins counter-regulate signs of inflammation
9. Production of 15-epi-lipoxins
10. Rapid screening: fast pace to stable analogs
11. 15-(R/S)-methyl LXA4 analog
12. LX and ATL deficiencies in human disease
13. From acute phase to resolution phase
14. Outcome of inflammation: complete resolution
15. Murine dorsal air pouch
16. LC-MS-MS based profiling of lipid mediators
17. LC-MS-MS results: 18R-HEPE
18. Resolvin E1 stops PMN infiltration
19. Biosynthesis of resolvin E1
20. Identification of novel lipid mediators
21. RvE1 in human plasma: mediator lipidomics
22. Resolvins: actions of E series resolvins
23. Resolvin E1: stereospecific total organic synthesis
24. Localized aggressive periodontitis (LAP)
25. Rabbit model for LAP
26. RvE1 protects from inflammatory bone loss
27. Receptor screening for counter-regulatory signals
28. Specific GPCRs for resolvin E1 actions
29. RvE1 acts via two distinct leukocyte GPCRs
30. RvE1 transformation
31. 19-para-fluoro-phenoxyl RvE1
32. DHA precursor to resolvins and protectins
33. Resolvins: actions of D series
34. RvD1 and ATRvD1: human PMN transmigration
35. Resolvins E and D series reduce murine peritonitis
36. Protectins: DHA-derived 17S-series
37. Biosynthesis of protectin D1/ neuroprotectin D1
38. PD1 stops leukocyte infiltration
39. Temporal-differential analyses of resolution
40. Resolution in quantitative terms
41. Upregulation of CCR5 during resolution
42. Resolvins and protectins in humans - summary
43. Resolvins and PD1 identified in murine kidney
44. PD1 and RvD1
45. Activity scores of mice treated with PD1 or RvDs
46. Discovery of a deficiency disease in rats
47. Normal vs. curled tail
48. Summation: some key points to remember
49. Resolvins and known pharmacological agents
50. Resolvins & protectins- summary
51. NIDCR
52. Laboratory of professor Charles N. Serhan

Topics Covered

• Complete resolution of the acute inflammatory response and its return to homeostasis is essential
• Efforts to identify and characterize the cellular and molecular mechanisms that govern resolution of self-limited inflammation
• Systems approach with temporal analysis of the evolving inflammatory exudates using unbiased mediator lipidomics/informatics, proteomics, and cellular traffic with murine resolving exudates
• Novel endogenous pathways of local acting mediators that are dual acting, and that are both anti-inflammatory and pro-resolving
• Biosynthesis and actions of "resolvins" and "protectins"
• E-series resolvins and D-series resolvins
• Actions of neuroprotectin D-1
• Biosynthesis of aspirin-triggered lipid mediators and their impact in regulating acute inflammatory responses
• The resolution of acute inflammation is an active process that can be accelerated

Links

Series:

• Innate Immunity

Categories:

• Biochemistry
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009
• Reviewed on May 1, 2020

Financial Disclosures

• Prof. Charles Serhan has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.