Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Catabolism of arginine: substrate supply
3. Catabolism of arginine: the Krebs urea cycle
4. Hepatocytes vs. macrophages
5. Regulation of iNOS transcription
6. Importance of iNOS in mycobacterial disease
7. Structure of arginases
8. Evidence for Arg1 regulation by Stat6 pathway
9. The type I and II IL-4 and IL-13 receptors
10. Mechanism of Arg1 regulation by Stat6 pathway
11. Regulation of Arg1 by the Stat3 pathway
12. Catabolism of arginine: Arg1 vs. iNOS
13. The substrate depletion concept
14. Norvaline
15. Catabolism of arginine, separation of powers
16. Arginases, NO and pathogenesis (1)
17. Arginases, NO and pathogenesis (2)
18. Arginase and in vivo regulation of NO
19. Arginase and in vivo regulation of NO (2)
20. Schistosome infection and Arg1(1)
21. Schistosome infection and Arg1(2)
22. Schistosome infection and AAMs
23. Severe periportal fibrosis, genetic components (1)
24. Severe periportal fibrosis, genetic components (2)
25. Macrophage Arg1 is essential for T cell response
26. What about macrophage Arg1 in asthma?
27. Arginase inhibitors
28. Arginase & NO: unresolved questions
29. Thank you

Topics Covered

• Catabolism of arginine to downstream substrates
• Catabolism of arginine in macrophages
• Nitric oxide production
• Control of iNOS at the transcriptional level
• Role of nitric oxide in immunity to intracellular pathogens with a focus on mycobacterial disease
• Structure of arginases
• Transcriptional control of arginase 1 in the liver vs. macrophages
• Arginases can suppress nitric oxide production by substrate depletion
• Pathogens use many mechanisms to regulate nitric oxide
• Arginases and alternatively-activated macrophages (AAMs)
• Schistosome infection as an example of AAM function
• AAMs and arginases
• Arginase inhibition by small molecules
• Outstanding questions

Links

Series:

• Innate Immunity

Categories:

• Biochemistry
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009
• Updated on August 31, 2011

Financial Disclosures

• Dr. Peter Murray has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.