• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 61 min
  2. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 42 min
  3. Eosinophils

  • Prof. Tim Williams
• Modulation of Effector Responses
• 22 min
  4. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  5. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 39 min
  6. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  7. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  8. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 27 min
  9. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 53 min
  10. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  11. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  12. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  13. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  14. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  15. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  16. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  17. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett
• 51 min
  18. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 61 min
  19. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 50 min
  20. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  21. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  22. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  23. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  24. Signaling by innate immune receptors

  • Prof. Michael Karin
• 38 min
  25. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  26. Innate immune sensing and response

  • Prof. Bruce Beutler
• 71 min
  27. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 54 min
  28. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 42 min
  29. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 25 min
  30. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 46 min
  31. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 41 min
  32. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• 44 min
  33. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 63 min
  34. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 39 min
  36. Innate immunity in children

  • Prof. David Speert
• 51 min
  37. Innate immunity and malaria

  • Prof. Douglas Golenbock
• 59 min
  38. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 54 min
  39. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 56 min
  40. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 38 min
  41. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 49 min
  42. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• 36 min
  43. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 41 min
  44. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• 50 min
  45. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Bacterial infection and inflammatory responses
3. The first step of activation
4. Pattern recognition receptors
5. The TLR family
6. Toll molecular structure
7. MyD88
8. The signalling pathways of Toll and TLR4
9. Components of the signaling pathway
10. NFkB as a central regulator
11. NFkB transcription in mammals
12. Ub modifications and their cellular functions
13. MAP kinase signaling pathways
14. LPS signaling pathways in human monocytes
15. TRAF3 and the signaling complex
16. Cytokines in TRAF3 deficient macrophages
17. The entire INF response is TRAF3 dependent
18. The TRAF3 signaling pathway
19. Negative regulation of TLR signaling
20. Pattern recognition receptors (2)
21. TNFalpha induced apoptosis
22. The TRAF family
23. CD40 signaling and its functions in B cells
24. The role of TRAFs in MAP kinase activation
25. Roles of TRAF proteins in CD40 signaling
26. Ubc13 E2 ubiquitin-conjugating enzyme
27. MEKK1 activation
28. CD40 complex assembly
29. CD40 complex release to cytosol
30. c-IAP1 and c-IAP2
31. The role of c-IAP1 and c-IAP2 in complex release
32. c-IAP2 target
33. Polyubiquitination of TRAF2 and TRAF3
34. c-IAP proteosome activity
35. A model for TNF MAP kinase activation
36. Why delay MAP kinase activity
37. IKKalpha dependent alternative pathway
38. Activation of IKKalpha by NIK
39. TRAF3 recruits TRAF2 and c-IAPs to NIK
40. cIAP1/2 regulate TRAF3 degradation
41. The E3 ligase activity of c-IAP2
42. A model for the alternative NFkB activation
43. Pattern recognition receptors (3)
44. The NLR Family
45. Pathogen-associated receptors
46. The inflammasomes and caspase-1
47. Mechanism of action of NALP3
48. Structure of the inflammasomes
49. NFkB as a negative regulator of the inflammasome
50. Regulation of IL-1beta production
51. NFkB activation in macrophages and neutrophiles
52. IL-1beta as an alternative immune response
53. IL-1beta response to LT is dependent
54. Summary

Topics Covered

• Understanding how receptors involved in the detection of infection (TLRs and NLRs) and inflammation (TNFRs) mediated their biological effects
• The activation of innate immune responses depends on recognition of infectious organisms (bacteria, fungi, viruses, etc.) by specialized pattern recognition receptors that include the large families of membrane-associated TLRs and cytosolic NLRs
• Signaling mechanisms used by TLRs and NLRs, as well as by TNFRs that respond to pro-inflammatory cytokines
• Their biological effects include the production of cytokines, chemokines, anti-microbial peptides and enzymes that generate inflammatory mediators and reactive oxygen

Links

Series:

• Innate Immunity

Categories:

• Biochemistry
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009
• Archived on May 28, 2025

Financial Disclosures

• Prof. Michael Karin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.