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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
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39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Bacterial infection and inflammatory responses
- The first step of activation
- Pattern recognition receptors
- The TLR family
- Toll molecular structure
- MyD88
- The signalling pathways of Toll and TLR4
- Components of the signaling pathway
- NFkB as a central regulator
- NFkB transcription in mammals
- Ub modifications and their cellular functions
- MAP kinase signaling pathways
- LPS signaling pathways in human monocytes
- TRAF3 and the signaling complex
- Cytokines in TRAF3 deficient macrophages
- The entire INF response is TRAF3 dependent
- The TRAF3 signaling pathway
- Negative regulation of TLR signaling
- Pattern recognition receptors (2)
- TNFalpha induced apoptosis
- The TRAF family
- CD40 signaling and its functions in B cells
- The role of TRAFs in MAP kinase activation
- Roles of TRAF proteins in CD40 signaling
- Ubc13 E2 ubiquitin-conjugating enzyme
- MEKK1 activation
- CD40 complex assembly
- CD40 complex release to cytosol
- c-IAP1 and c-IAP2
- The role of c-IAP1 and c-IAP2 in complex release
- c-IAP2 target
- Polyubiquitination of TRAF2 and TRAF3
- c-IAP proteosome activity
- A model for TNF MAP kinase activation
- Why delay MAP kinase activity
- IKKalpha dependent alternative pathway
- Activation of IKKalpha by NIK
- TRAF3 recruits TRAF2 and c-IAPs to NIK
- cIAP1/2 regulate TRAF3 degradation
- The E3 ligase activity of c-IAP2
- A model for the alternative NFkB activation
- Pattern recognition receptors (3)
- The NLR Family
- Pathogen-associated receptors
- The inflammasomes and caspase-1
- Mechanism of action of NALP3
- Structure of the inflammasomes
- NFkB as a negative regulator of the inflammasome
- Regulation of IL-1beta production
- NFkB activation in macrophages and neutrophiles
- IL-1beta as an alternative immune response
- IL-1beta response to LT is dependent
- Summary
Topics Covered
- Understanding how receptors involved in the detection of infection (TLRs and NLRs) and inflammation (TNFRs) mediated their biological effects
- The activation of innate immune responses depends on recognition of infectious organisms (bacteria, fungi, viruses, etc.) by specialized pattern recognition receptors that include the large families of membrane-associated TLRs and cytosolic NLRs
- Signaling mechanisms used by TLRs and NLRs, as well as by TNFRs that respond to pro-inflammatory cytokines
- Their biological effects include the production of cytokines, chemokines, anti-microbial peptides and enzymes that generate inflammatory mediators and reactive oxygen
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Karin, M. (2009, May 31). Signaling by innate immune receptors [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 8, 2024, from https://doi.org/10.69645/GCIX3503.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Michael Karin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Signaling by innate immune receptors
Published on May 31, 2009
38 min
