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1. Introduction
2. Bacterial infection and inflammatory responses
3. The first step of activation
4. Pattern recognition receptors
5. The TLR family
6. Toll molecular structure
7. MyD88
8. The signalling pathways of Toll and TLR4
9. Components of the signaling pathway
10. NFkB as a central regulator
11. NFkB transcription in mammals
12. Ub modifications and their cellular functions
13. MAP kinase signaling pathways
14. LPS signaling pathways in human monocytes
15. TRAF3 and the signaling complex
16. Cytokines in TRAF3 deficient macrophages
17. The entire INF response is TRAF3 dependent
18. The TRAF3 signaling pathway
19. Negative regulation of TLR signaling
20. Pattern recognition receptors (2)
21. TNFalpha induced apoptosis
22. The TRAF family
23. CD40 signaling and its functions in B cells
24. The role of TRAFs in MAP kinase activation
25. Roles of TRAF proteins in CD40 signaling
26. Ubc13 E2 ubiquitin-conjugating enzyme
27. MEKK1 activation
28. CD40 complex assembly
29. CD40 complex release to cytosol
30. c-IAP1 and c-IAP2
31. The role of c-IAP1 and c-IAP2 in complex release
32. c-IAP2 target
33. Polyubiquitination of TRAF2 and TRAF3
34. c-IAP proteosome activity
35. A model for TNF MAP kinase activation
36. Why delay MAP kinase activity
37. IKKalpha dependent alternative pathway
38. Activation of IKKalpha by NIK
39. TRAF3 recruits TRAF2 and c-IAPs to NIK
40. cIAP1/2 regulate TRAF3 degradation
41. The E3 ligase activity of c-IAP2
42. A model for the alternative NFkB activation
43. Pattern recognition receptors (3)
44. The NLR Family
45. Pathogen-associated receptors
46. The inflammasomes and caspase-1
47. Mechanism of action of NALP3
48. Structure of the inflammasomes
49. NFkB as a negative regulator of the inflammasome
50. Regulation of IL-1beta production
51. NFkB activation in macrophages and neutrophiles
52. IL-1beta as an alternative immune response
53. IL-1beta response to LT is dependent
54. Summary

Topics Covered

• Understanding how receptors involved in the detection of infection (TLRs and NLRs) and inflammation (TNFRs) mediated their biological effects
• The activation of innate immune responses depends on recognition of infectious organisms (bacteria, fungi, viruses, etc.) by specialized pattern recognition receptors that include the large families of membrane-associated TLRs and cytosolic NLRs
• Signaling mechanisms used by TLRs and NLRs, as well as by TNFRs that respond to pro-inflammatory cytokines
• Their biological effects include the production of cytokines, chemokines, anti-microbial peptides and enzymes that generate inflammatory mediators and reactive oxygen

Links

Series:

• Innate Immunity

Categories:

• Biochemistry
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Michael Karin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.