• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. In the beginning there was the word
3. Inflammation
4. 1974 - Ivan Roitt's historical perspectives
5. Ilya Mechnikov - the inventor of phagocytic theory
6. Mechnikov's findings
7. Inflammation - white blood cells
8. Inflammation re-invented as innate immunity
9. Andrew McMichael - immunologists point of view
10. Polymorphic nuclear leukocytes - TEM image
11. X-ray representing pneumococcal pneumonia
12. Histological view of pneumococcal pneumonia
13. The histological view after treatment
14. How are neutrophils removed from inflamed sites?
15. Apoptosis of neutrophils from arthritis patients
16. Apoptosis vs. necrosis
17. Apoptosis in neutrophil
18. A view of the ingested apoptotic cell
19. How are apoptotic cells recognized as non-self?
20. The complexity of the process in mammals (1)
21. The process in C. elegans
22. The complexity of the process in mammals (2)
23. The meaning of cell death
24. Suppression of inflammation
25. Apoptotic cells block inflammatory cytokines
26. Apoptotic cell phagocytosis is anti-inflammatory
27. Reprogramming is TGF-beta dependent
28. What does apoptotic cell clearance lead to?
29. R-roscovitine promotes resolution of inflammation
30. Regulation of immune responses
31. DCs ingest apoptotic cells
32. DCs culture experiment
33. Apoptotic cells inhibit DC maturation (1)
34. Apoptotic cells inhibit DC maturation (2)
35. DCs containing apoptotic cells: poor stimulators
36. DC ingestion induces CD4+FoxP3+ T regs
37. Apoptosis and regulatory T cells
38. Apoptotic cell infusion presents GvHD
39. Knockout of alphaV in the myeloid line (1)
40. Knockout of alphaV in the myeloid line (2)
41. Susceptibility of KO mice to inflammation (1)
42. Susceptibility of KO mice to inflammation (2)
43. The immune system is active before illness occurs
44. The effect of the knockout on FoxP3 + cells
45. AlphaV role in inflammation - summary (1)
46. AlphaV role in inflammation - summary (2)
47. T regs dampen primary Pneumocystis pneumonia
48. Can clearance of apoptotic cells induce T regs?
49. Acknowledgements

Topics Covered

• Historical perspective
• Inflammation re-invented as innate immunity
• Clearance by phagocytes defines the meaning of cell death
• Suppression of inflammation
• Apoptotic cell phagocytosis
• Reprogramming
• Regulation of immune responses
• DCs ingest apoptotic cells
• Apoptotic cells inhibit DC maturation
• Apoptosis and regulatory T cells
• Modulation of parasite infestation
• Control of macrophage-directed cell death

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009
• Archived on May 28, 2025

Financial Disclosures

• Prof. Sir John Savill has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.