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1. Introduction
2. In the beginning there was the word
3. Inflammation
4. 1974 - Ivan Roitt's historical perspectives
5. Ilya Mechnikov - the inventor of phagocytic theory
6. Mechnikov's findings
7. Inflammation - white blood cells
8. Inflammation re-invented as innate immunity
9. Andrew McMichael - immunologists point of view
10. Polymorphic nuclear leukocytes - TEM image
11. X-ray representing pneumococcal pneumonia
12. Histological view of pneumococcal pneumonia
13. The histological view after treatment
14. How are neutrophils removed from inflamed sites?
15. Apoptosis of neutrophils from arthritis patients
16. Apoptosis vs. necrosis
17. Apoptosis in neutrophil
18. A view of the ingested apoptotic cell
19. How are apoptotic cells recognized as non-self?
20. The complexity of the process in mammals (1)
21. The process in C. elegans
22. The complexity of the process in mammals (2)
23. The meaning of cell death
24. Suppression of inflammation
25. Apoptotic cells block inflammatory cytokines
26. Apoptotic cell phagocytosis is anti-inflammatory
27. Reprogramming is TGF-beta dependent
28. What does apoptotic cell clearance lead to?
29. R-roscovitine promotes resolution of inflammation
30. Regulation of immune responses
31. DCs ingest apoptotic cells
32. DCs culture experiment
33. Apoptotic cells inhibit DC maturation (1)
34. Apoptotic cells inhibit DC maturation (2)
35. DCs containing apoptotic cells: poor stimulators
36. DC ingestion induces CD4+FoxP3+ T regs
37. Apoptosis and regulatory T cells
38. Apoptotic cell infusion presents GvHD
39. Knockout of alphaV in the myeloid line (1)
40. Knockout of alphaV in the myeloid line (2)
41. Susceptibility of KO mice to inflammation (1)
42. Susceptibility of KO mice to inflammation (2)
43. The immune system is active before illness occurs
44. The effect of the knockout on FoxP3 + cells
45. AlphaV role in inflammation - summary (1)
46. AlphaV role in inflammation - summary (2)
47. T regs dampen primary Pneumocystis pneumonia
48. Can clearance of apoptotic cells induce T regs?
49. Acknowledgements

Topics Covered

• Historical perspective
• Inflammation re-invented as innate immunity
• Clearance by phagocytes defines the meaning of cell death
• Suppression of inflammation
• Apoptotic cell phagocytosis
• Reprogramming
• Regulation of immune responses
• DCs ingest apoptotic cells
• Apoptotic cells inhibit DC maturation
• Apoptosis and regulatory T cells
• Modulation of parasite infestation
• Control of macrophage-directed cell death

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Savill, J. (2009, May 31). Clearance of apoptotic cells and the control of inflammation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/OTSI5107.
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Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Sir John Savill has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.