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1. Introduction
2. Colony formation by hematopoietic cells
3. Colony stimulating factors (CSFs)
4. CSF-1 in development and disease
5. Regulation by CSF-1 in development
6. CSF-1-deficient (Csf1op/Csf1op) mice
7. Biosynthesis and expression of CSF-1
8. Csf1 promoter-driven CSF-1 transgenes
9. CSF-1R-nullizygous mice
10. CSF-1R-nullizygous mice - conclusions
11. Interleukin-34 - a novel ligand for the CSF-1R
12. CSF-1 transgenic and Csf1r-/- mice
13. CSF-1 in disease: insights from animal models
14. Blocking CSF-1 action as therapy
15. Anti-CSF1 antibody treatment blocks CSF-1 action
16. CSF-1 and the CSF-1R in leukemia
17. CSF-1 and solid tumors
18. CSF-1 blockade inhibits tumor development
19. A tumor cell/macrophage paracrine loop
20. CSF1/CSF1R mouse genetic models and disease
21. Early events in CSF-1 signal transduction
22. The macrophage CSF-1R signaling proteome
23. CSF-1 signaling proteome interaction map
24. MAYP/PSTPIP2
25. MAYP/PSTPIP2 and the PCH family
26. PCH proteins in vesicle and filopod formation
27. Pstpip2 mutations cause inflammatory disease
28. Gross phenotype of the Lupo mutation
29. Macrophage infiltration in Pstpip2Lp/Lp mice
30. Pstpip2Lp/Lp disease
31. CSF-1 R structure
32. The MacCsf1r-/- (M-/-) macrophage cell line
33. Phenotypes of CSF-1R Y->F mutant macrophages
34. Morphology of CSF-1R Y->F mutant macrophages
35. CSF-1R mutant macrophage cell lines
36. Current questions in CSF-1/CSF-1R research
37. Acknowledgements

Topics Covered

• Colony stimulating factors
• Action of CSF-1 and its isoforms
• The CSF-1 receptor (CSF-1R) and its new ligand, IL-34
• CSF-1 and the CSF-1R in mouse models of inflammatory disease and cancer
• A proteomic approach CSF-1R signaling
• Action of the downstream signaling molecule, PSTPIP2
• PSTPIP2 mutations cause autoinflammatory disease
• A genetic approach to CSF-1R structure/function and signaling
• Current questions

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Stanley, E.R. (2009, May 31). Colony stimulating factor-1 regulation of macrophages in development and disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/WULU3350.
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Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. E. Richard Stanley has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.