• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Outline
3. Innate like lymphocytes
4. Structural representation of antigen receptors
5. Innate-like lymphocytes
6. Innate-like T cells and tissue immune surveillance
7. Immune surveillance
8. Immune cells are associated with tissues
9. Information flow: from challenge to DC to T cell
10. Immune response by conventional lymphocytes
11. Innate and adaptive immunity - a sequence
12. Conventional immunity strength and weaknesses
13. Tissue associated T cells
14. IEL - one of the largest T cell subsets
15. Gamma-delta T cells
16. Gamma-delta receptor
17. Gamma-delta gene segments
18. A third, unanticipated, type of lymphocyte (1)
19. Gamma-delta cells - "innate-like" properties
20. Tissue associated T cells with a limited repertoire
21. Phenotypes of "innate-like" T cells
22. Intestinal intraepithelial lymphocytes
23. A third, unanticipated, type of lymphocyte (2)
24. A novel form of immune response
25. Stress induced MHC class 1b
26. Gamma-delta T cell/epithelial cell interactions
27. Hypothesis regarding "innate-like" T cells
28. Testing the hypothesis
29. Effects of inducing Rae-1beta
30. Rae-1 induction rapidly promotes infiltration
31. NKT cell infiltration in response to Rae-1
32. Summary of the effects of Rae-1beta induction
33. Revised perspective on tissue immune surveillance
34. The benefits of unconventional T cells
35. A role for gamma-delta T cells in carcinogenesis
36. Early tumor surveillance
37. Spontaneous pathology in TCRgamma-/- mouse(1)
38. Spontaneous pathology in TCRgamma-/- mouse(2)
39. Phenotypic rescue with precursors of DETC
40. Summary of section 1
41. Application of such concepts to human disease
42. Key cells that bear the NKG2D receptor
43. Direct activation of tissue-associated lymphocytes
44. Functional differentiation of Innate-like T cells
45. "Slow" activation of adaptive lymphoid cells
46. "Fast" activation of innate-like lymphocytes?
47. Discrete (CD27+/-) gamma-delta cell subsets
48. Differentiation of gamma-delta T cells
49. Cytokines production in CD27-/- mice
50. Gamma-delta cell development in the thymus
51. Different T cells development
52. Working model- acquiring functional competence
53. Section 2: interim conclusions
54. Gamma-delta cells and virus infection: case 1
55. Gamma-delta cells and virus infection: case 2
56. Gamma-delta cells and virus infection: case 3
57. Gamma-delta cells and bacterial infection - case 4
58. Different unconventional T cell subtypes
59. Immunity in the very young

Topics Covered

• Innate like lymphocytes
• Structural representation of antigen receptors
• Introduction to "unconventional" lymphocytes
• Innate-like T cells and tissue immune surveillance
• Information flow: from challenge to DC to T cell
• Immune response by conventional lymphocytes
• Conventional immunity strength and weaknesses
• Tissue associated T cells
• IEL
• one of the largest T cell subsets
• Gamma-delta T cells, receptor and gene segment
• Phenotypes of "innate-like" T cells
• Intestinal intraepithelial lymphocytes
• Stress induced MHC class 1B
• Rae-1 induction rapidly promotes infiltration
• A role for gamma-delta T cells in carcinogenesis
• Early tumor surveillance
• Spontaneous pathology in TCRgamma-/- mouse
• Phenotypic rescue with precursors of DETC
• Application human disease
• Key cells that bear the NKG2D receptor
• Direct activation of tissue-associated lymphocytes
• Functional differentiation of Innate-like T cells
• "Slow" activation of adaptive lymphoid cells
• "Fast" activation of innate-like lymphocytes?
• Discrete (CD27+/-) gamma-delta cell subsets
• Cytokines production in CD27-/- mice
• Gamma-delta cell development in the thymus
• Acquiring functional competence working model
• Gamma-delta cells and virus/bacterial infection
• Immunity in the very young

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on July 15, 2009

Financial Disclosures

• Prof. Adrian Hayday has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.