Inflammation: purposes, mechanisms and development
47 min
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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
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39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Innate like lymphocytes
- Structural representation of antigen receptors
- Innate-like lymphocytes
- Innate-like T cells and tissue immune surveillance
- Immune surveillance
- Immune cells are associated with tissues
- Information flow: from challenge to DC to T cell
- Immune response by conventional lymphocytes
- Innate and adaptive immunity - a sequence
- Conventional immunity strength and weaknesses
- Tissue associated T cells
- IEL - one of the largest T cell subsets
- Gamma-delta T cells
- Gamma-delta receptor
- Gamma-delta gene segments
- A third, unanticipated, type of lymphocyte (1)
- Gamma-delta cells - "innate-like" properties
- Tissue associated T cells with a limited repertoire
- Phenotypes of "innate-like" T cells
- Intestinal intraepithelial lymphocytes
- A third, unanticipated, type of lymphocyte (2)
- A novel form of immune response
- Stress induced MHC class 1b
- Gamma-delta T cell/epithelial cell interactions
- Hypothesis regarding "innate-like" T cells
- Testing the hypothesis
- Effects of inducing Rae-1beta
- Rae-1 induction rapidly promotes infiltration
- NKT cell infiltration in response to Rae-1
- Summary of the effects of Rae-1beta induction
- Revised perspective on tissue immune surveillance
- The benefits of unconventional T cells
- A role for gamma-delta T cells in carcinogenesis
- Early tumor surveillance
- Spontaneous pathology in TCRgamma-/- mouse(1)
- Spontaneous pathology in TCRgamma-/- mouse(2)
- Phenotypic rescue with precursors of DETC
- Summary of section 1
- Application of such concepts to human disease
- Key cells that bear the NKG2D receptor
- Direct activation of tissue-associated lymphocytes
- Functional differentiation of Innate-like T cells
- "Slow" activation of adaptive lymphoid cells
- "Fast" activation of innate-like lymphocytes?
- Discrete (CD27+/-) gamma-delta cell subsets
- Differentiation of gamma-delta T cells
- Cytokines production in CD27-/- mice
- Gamma-delta cell development in the thymus
- Different T cells development
- Working model- acquiring functional competence
- Section 2: interim conclusions
- Gamma-delta cells and virus infection: case 1
- Gamma-delta cells and virus infection: case 2
- Gamma-delta cells and virus infection: case 3
- Gamma-delta cells and bacterial infection - case 4
- Different unconventional T cell subtypes
- Immunity in the very young
Topics Covered
- Innate like lymphocytes
- Structural representation of antigen receptors
- Introduction to "unconventional" lymphocytes
- Innate-like T cells and tissue immune surveillance
- Information flow: from challenge to DC to T cell
- Immune response by conventional lymphocytes
- Conventional immunity strength and weaknesses
- Tissue associated T cells
- IEL
- one of the largest T cell subsets
- Gamma-delta T cells, receptor and gene segment
- Phenotypes of "innate-like" T cells
- Intestinal intraepithelial lymphocytes
- Stress induced MHC class 1B
- Rae-1 induction rapidly promotes infiltration
- A role for gamma-delta T cells in carcinogenesis
- Early tumor surveillance
- Spontaneous pathology in TCRgamma-/- mouse
- Phenotypic rescue with precursors of DETC
- Application human disease
- Key cells that bear the NKG2D receptor
- Direct activation of tissue-associated lymphocytes
- Functional differentiation of Innate-like T cells
- "Slow" activation of adaptive lymphoid cells
- "Fast" activation of innate-like lymphocytes?
- Discrete (CD27+/-) gamma-delta cell subsets
- Cytokines production in CD27-/- mice
- Gamma-delta cell development in the thymus
- Acquiring functional competence working model
- Gamma-delta cells and virus/bacterial infection
- Immunity in the very young
Talk Citation
Hayday, A. (2009, July 15). Innate-like lymphocytes 1 [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved September 22, 2023, from https://hstalks.com/bs/1290/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Adrian Hayday has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Innate-like lymphocytes 1
Published on July 15, 2009
61 min
