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1. Introduction
2. Outline
3. Innate like lymphocytes
4. Structural representation of antigen receptors
5. Innate-like lymphocytes
6. Innate-like T cells and tissue immune surveillance
7. Immune surveillance
8. Immune cells are associated with tissues
9. Information flow: from challenge to DC to T cell
10. Immune response by conventional lymphocytes
11. Innate and adaptive immunity - a sequence
12. Conventional immunity strength and weaknesses
13. Tissue associated T cells
14. IEL - one of the largest T cell subsets
15. Gamma-delta T cells
16. Gamma-delta receptor
17. Gamma-delta gene segments
18. A third, unanticipated, type of lymphocyte (1)
19. Gamma-delta cells - "innate-like" properties
20. Tissue associated T cells with a limited repertoire
21. Phenotypes of "innate-like" T cells
22. Intestinal intraepithelial lymphocytes
23. A third, unanticipated, type of lymphocyte (2)
24. A novel form of immune response
25. Stress induced MHC class 1b
26. Gamma-delta T cell/epithelial cell interactions
27. Hypothesis regarding "innate-like" T cells
28. Testing the hypothesis
29. Effects of inducing Rae-1beta
30. Rae-1 induction rapidly promotes infiltration
31. NKT cell infiltration in response to Rae-1
32. Summary of the effects of Rae-1beta induction
33. Revised perspective on tissue immune surveillance
34. The benefits of unconventional T cells
35. A role for gamma-delta T cells in carcinogenesis
36. Early tumor surveillance
37. Spontaneous pathology in TCRgamma-/- mouse(1)
38. Spontaneous pathology in TCRgamma-/- mouse(2)
39. Phenotypic rescue with precursors of DETC
40. Summary of section 1
41. Application of such concepts to human disease
42. Key cells that bear the NKG2D receptor
43. Direct activation of tissue-associated lymphocytes
44. Functional differentiation of Innate-like T cells
45. "Slow" activation of adaptive lymphoid cells
46. "Fast" activation of innate-like lymphocytes?
47. Discrete (CD27+/-) gamma-delta cell subsets
48. Differentiation of gamma-delta T cells
49. Cytokines production in CD27-/- mice
50. Gamma-delta cell development in the thymus
51. Different T cells development
52. Working model- acquiring functional competence
53. Section 2: interim conclusions
54. Gamma-delta cells and virus infection: case 1
55. Gamma-delta cells and virus infection: case 2
56. Gamma-delta cells and virus infection: case 3
57. Gamma-delta cells and bacterial infection - case 4
58. Different unconventional T cell subtypes
59. Immunity in the very young

Topics Covered

• Innate like lymphocytes
• Structural representation of antigen receptors
• Introduction to "unconventional" lymphocytes
• Innate-like T cells and tissue immune surveillance
• Information flow: from challenge to DC to T cell
• Immune response by conventional lymphocytes
• Conventional immunity strength and weaknesses
• Tissue associated T cells
• IEL
• one of the largest T cell subsets
• Gamma-delta T cells, receptor and gene segment
• Phenotypes of "innate-like" T cells
• Intestinal intraepithelial lymphocytes
• Stress induced MHC class 1B
• Rae-1 induction rapidly promotes infiltration
• A role for gamma-delta T cells in carcinogenesis
• Early tumor surveillance
• Spontaneous pathology in TCRgamma-/- mouse
• Phenotypic rescue with precursors of DETC
• Application human disease
• Key cells that bear the NKG2D receptor
• Direct activation of tissue-associated lymphocytes
• Functional differentiation of Innate-like T cells
• "Slow" activation of adaptive lymphoid cells
• "Fast" activation of innate-like lymphocytes?
• Discrete (CD27+/-) gamma-delta cell subsets
• Cytokines production in CD27-/- mice
• Gamma-delta cell development in the thymus
• Acquiring functional competence working model
• Gamma-delta cells and virus/bacterial infection
• Immunity in the very young

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on July 15, 2009

Financial Disclosures

• Prof. Adrian Hayday has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.