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Printable Handouts
Navigable Slide Index
- Introduction
- Pathologists (1958 to 1980s)
- Virologist, Immunologists (1970s)
- Identification of plasmacytoid DC
- Isolation of human plasmacytoid pre-DCs
- Electron microscopy of plasmacytoid DC
- Plasmacytoid DC is an interferon producing cell
- Kinetic of pDCs to produce type 1 IFNs
- pDC's new transcription during anti-viral response
- Repertoire of type 1 IFN response by pDCs
- pDC as innate effector cell against viral infection
- Can IPC/pDC be generated from stem cells?
- Localization of pDC and mDC
- Linking innate and adaptive immunity - pDC/IPC
- The functions of pDC
- TLR expression by pDC and mDC
- pDC sense viral DNA and RNA
- pDC-sense self-DNA in autoimmune diseases
- Factors capable of binding self-DNA
- Microarray of human immune cells
- pDC receptors
- ILT7 and BDCA2 are two pDC specific receptors
- Hematopoietic immune receptors
- Human pDCs express 3 transmembrane adaptors
- ILT7 associates with Fc-epsilon-R1-gamma
- ITAM signaling
- Inhibition of TLR responses in pDCs
- Summary
- ILT7 reporter cell system
- Breast cancer cell lines express an ILT7 ligand
- Generate mAb to identify ILT7 ligand (1)
- Generate mAb to identify ILT7 ligand (2)
- Identify ILT7 ligand
- Characterizing BST2
- BST2 negatively regulate pDC's IFN response
- Acknowledgements
Topics Covered
- Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection
- This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes
- Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them
- In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling
- Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis
Talk Citation
Liu, Y. (2009, June 30). Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 5, 2024, from https://doi.org/10.69645/MEGI4877.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Yong-Jun Liu has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity
Published on June 30, 2009
25 min
A selection of talks on Immunology
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