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1. Introduction
2. Pathologists (1958 to 1980s)
3. Virologist, Immunologists (1970s)
4. Identification of plasmacytoid DC
5. Isolation of human plasmacytoid pre-DCs
6. Electron microscopy of plasmacytoid DC
7. Plasmacytoid DC is an interferon producing cell
8. Kinetic of pDCs to produce type 1 IFNs
9. pDC's new transcription during anti-viral response
10. Repertoire of type 1 IFN response by pDCs
11. pDC as innate effector cell against viral infection
12. Can IPC/pDC be generated from stem cells?
13. Localization of pDC and mDC
14. Linking innate and adaptive immunity - pDC/IPC
15. The functions of pDC
16. TLR expression by pDC and mDC
17. pDC sense viral DNA and RNA
18. pDC-sense self-DNA in autoimmune diseases
19. Factors capable of binding self-DNA
20. Microarray of human immune cells
21. pDC receptors
22. ILT7 and BDCA2 are two pDC specific receptors
23. Hematopoietic immune receptors
24. Human pDCs express 3 transmembrane adaptors
25. ILT7 associates with Fc-epsilon-R1-gamma
26. ITAM signaling
27. Inhibition of TLR responses in pDCs
28. Summary
29. ILT7 reporter cell system
30. Breast cancer cell lines express an ILT7 ligand
31. Generate mAb to identify ILT7 ligand (1)
32. Generate mAb to identify ILT7 ligand (2)
33. Identify ILT7 ligand
34. Characterizing BST2
35. BST2 negatively regulate pDC's IFN response
36. Acknowledgements

Topics Covered

• Plasmacytoid dendritic cells (pDCs) are important mediators of antiviral immunity through their ability to produce large amounts of type I interferons (IFNs) on viral infection
• This function of pDCs is linked to their expression of Toll-like receptor 7 (TLR7) and TLR9, which sense viral nucleic acids within the early endosomes
• Exclusion of self nucleic acids from TLR-containing early endosomes normally prevents pDC responses to them
• In some autoimmune diseases, self nucleic acids can be modified by host factors and gain entrance to pDC endosomes, where they activate TLR signaling
• Several pDC receptors negatively regulate type I IFN responses by pDCs during viral infection and for normal homeostasis

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Liu, Y. (2009, June 30). Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 21, 2024, from https://doi.org/10.69645/MEGI4877.
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Publication History

• Published on June 30, 2009

Financial Disclosures

• Prof. Yong-Jun Liu has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.