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- Models of Investigation
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1. Antifungal innate immunity in C. elegans
- Dr. Jonathan Ewbank
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2. The anti-microbial defense of Drosophila: a paradigm for innate immunity
- Prof. Jules Hoffmann
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3. Phagocytosis in the fruit fly, Drosophila melanogaster
- Dr. Lynda Stuart
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4. Innate immune sensing and response
- Prof. Bruce Beutler
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5. Macrophages and systems biology
- Prof. David Hume
- Cell Types and Recruitment
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6. Leukocyte recruitment in vivo
- Prof. Paul Kubes
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8. Eosinophils
- Prof. Tim Williams
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9. Dendritic cells: linking innate to different forms of adaptive immunity
- Prof. Ralph Steinman
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11. Innate-like lymphocytes 1
- Prof. Adrian Hayday
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12. Innate-like lymphocytes 2
- Prof. Adrian Hayday
- Recognition and Signaling
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13. Colony stimulating factor-1 regulation of macrophages in development and disease
- Prof. E. Richard Stanley
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14. Fc receptors: linking innate and acquired immunity
- Prof. Ken G C Smith
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15. Phagocytosis
- Prof. Joel Swanson
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16. Clearance of apoptotic cells and the control of inflammation
- Prof. Sir John Savill
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17. Signaling by innate immune receptors
- Prof. Michael Karin
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18. Nuclear receptors at the crossroads of inflammation and atherosclerosis
- Prof. Christopher Glass
- Modulation of Effector Responses
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19. Humoral innate immunity and the acute phase response 1
- Prof. Alberto Mantovani from humanitas.it
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20. Humoral innate immunity and the acute phase response 2
- Prof. Alberto Mantovani from humanitas.it
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21. Cytokines regulating the innate response
- Prof. Anne O’Garra
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22. Arginase and nitric oxide
- Dr. Peter Murray
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23. Novel lipid mediators in resolution of inflammation
- Prof. Charles Serhan
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25. Cationic peptides in innate immunity
- Dr. Dawn Bowdish
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26. Iron metabolism and innate immunity
- Prof. Tomas Ganz
- Pathogen-Host Interactions
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27. Innate recognition of viruses
- Prof. Caetano Reis e Sousa
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28. Type I interferons in innate immunity to viral infections
- Prof. Christine Biron
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29. HIV-1 and immunopathogenesis: innate immunity
- Prof. Luis Montaner
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30. Understanding and combating tuberculosis
- Prof. David Russell
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32. Innate immunity and malaria
- Prof. Douglas Golenbock
- Health and Disease
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33. Innate immunity in children
- Prof. David Speert
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34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis
- Prof. Sir Ravinder Maini
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35. NOD-like receptors in innate immunity and inflammatory disease
- Prof. Gabriel Nunez
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36. Paneth cells in innate immunity and inflammatory bowel disease
- Prof. Satish Keshav
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37. Innate immunity in the brain in health and disease
- Prof. V. Hugh Perry
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38. The fate of monocytes in atherosclerosis
- Prof. Gwendolyn Randolph
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39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis
- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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40. Monocyte/macrophages in innate immunity
- Prof. Emeritus Siamon Gordon
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41. Innate immunity in C. elegans
- Dr. Jonathan Ewbank
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43. NLR genes: infection, inflammation and vaccines
- Prof. Jenny Ting
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44. Manipulation of innate immune response: lessons from shigella
- Prof. Philippe Sansonetti
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45. Innate immunity of the lung and adaptation to air breathing at birth
- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- History of the science of immunology
- Two theories of immunity
- Initiation of antibody responses in tissue culture
- Identification and purification of mouse DCs
- Zanvil A. Cohn and Ralph M. Steinman
- The first recognized function of dendritic cells
- The mixed leukocyte reaction in vitro
- The initiation of transplant rejection in vivo
- Peter Medawar and James L. Gowans
- Features of T cell responses initiated by DCs
- T helper-dependent antibody production
- Formation of cytotoxic T lymphocytes (CTL)
- Microenvironment for generating immunity
- DCs: "nature's adjuvants" for T cell immunity
- Initiating immunity or "immunogenicity"
- First investigators of antigen presentation by DCs
- Features of innate vs. adaptive immunity
- Dendritic cells and innate immunity
- How DCs facilitate innate and adaptive immunity
- Some locations for antigen capturing DCs
- Dendritic cells within airway epithelium
- Diagram of a lymph node
- DCs in T cell areas of mouse lymph node
- DC in T cell area of peripheral lymphoid organs
- Modern approach for detecting DCs in T cells area
- Visualizing DCs in vivo, also in intact living tissues
- DCs' antigen capture, processing and presentation
- Targeting of anti-langerin/CD207 to DCs in vivo
- Delivering a protein to dendritic cells in vivo
- Monitoring uptake, processing and presentation
- Example: antibody-targeted ovalbumin
- Example: antibody-targeted LACK
- Anti-DEC-HIV-gag as an AIDS vaccine
- Cross presentation of antigens by dendritic cells
- Antigen handling by DCs: current concepts
- Maturation of dendritic cells
- Some stimuli and components of DC maturation
- Pattern recognition receptors in dendritic cells
- Changes in cell surface markers during maturation
- Example: LACK delivery via DEC-205 w. adjuvant
- Dendritic cell maturation - summary
- Some subsets of dendritic cells in steady state
- Dendritic cells (Langerhans cells) in epidermis
- Langerhans cells after maturation
- Nikolaus Romani and Gerold Schuler
- Induction of antigen-specific peripheral tolerance
- Capture of antigens by DCs in steady state
- Iduction of tolerance vs. immunity by DCs
- Controlling antigen-specific tolerance in vivo
- Putting the features of dendritic cells together
- The bright future of immunology in human disease
- DCs and disease-related immunity
- Autoimmune and autoinflammatory diseases
- TNF in psoriatic skin is expressed in CD11c+ cells
- Dendritic cells and new vaccines
- Vaccines-related, important goal for immunology
- Histrory of vaccines
- Medicine needs new vaccine success stories
- Vaccines: interface of immunology and medicine
- Harnessing DCs for control of the immune system
- Ex vivo generation of antigen-bearing DCs
- Ex vivo generation of highly enriched human DCs
- Ex vivo dendritic cells for cancer research
- Collaborative research, stimulating vaccine science
- Combining antigens delivery and maturation stimuli
- Example: response to combined vaccine in mouse
- DEC-205/CD205 expression on DCs
- Obstacles to anti-DEC-HIV protein vaccines
- A proposal
- New cell type within the elegant immune orchestra
- Energizing the clonal selection theory of immunity
- Macfarlane Burnet
- Overcoming the hurdles to control T cell function
- The many interfaces of immunology and medicine
- Principles and approaches to vaccines
- Sources of support for the research
- Thanks to former and current PI's in the lab
Topics Covered
- Identification of a new cell type
- Initiating immunity
- Features of dendritic cells
- Interfaces with medicine
- New approaches to vaccine
Talk Citation
Steinman, R. (2009, May 31). Dendritic cells: linking innate to different forms of adaptive immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 9, 2024, from https://doi.org/10.69645/PJJU6376.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Ralph Steinman has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
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