Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Significant figures in macrophage research
3. Human diseases of innate immunity
4. Macrophages in innate immunity
5. Talk outline
6. Differentiation and distribution of macrophages
7. The EGF-TM7 family
8. Macrophages remodel tissues in development
9. Kupffer cells F4/80+
10. Resident tissue macrophages' microheterogeneity
11. Differentiation of monocytes
12. F4/80+ Langerhans cell in normal skin
13. Differentiation of microglia
14. Trophic interaction: haematopoiesis
15. Haematopoietic stroma
16. F4/80 in red pulp spleen
17. Sialoadhesin in marginal zone of spleen
18. Marginal zone
19. Monocyte recruitment
20. Experimental models: sterile mouse peritonitis
21. BCG granulomata
22. Lysozyme expression in activated macrophages
23. Monocyte heterogeneity and recruitment
24. Differential activation of macrophages
25. Phagocytosis of apoptotic thymocyte
26. Antibody coated erythrocytes (EIgG)
27. Phagocytic pathway
28. APC pattern recognition receptors
29. APC receptors
30. Sensors of pattern recognition
31. Macrophage receptors
32. Macrophage interactions
33. Dectin-1
34. Dectin-1 recognises beta 1-3/6 linked glucans
35. Zymosan induced TNF-alpha production
36. Dectin-1 tail is required for cytokine secretion
37. Dectin-1 ITAM like motif is required for ingestion
38. Dectin-1 collaborates with TLR in signalling
39. Fungal walls are rich in beta glucan
40. Uptake of C. albicans by macrophages
41. Candida infection in dectin-1-deficient mice
42. Mannose receptor (MR): overview
43. Mannose receptor
44. Reagents used in search for MR ligands
45. CRD4-7Fc recognises ligands in secretory organs
46. Ligands for the cysteine-rich domain of the MR
47. The sMR-mediated Ag delivery hypothesis
48. A subset of Met macrophages express CR-ligands
49. CR-ligand+ cells migrate in response to LPS
50. LPS increases the humoral response
51. Scavenger receptors
52. Scavenger receptor A
53. Meningococcal septicaemia, haemorrhagic rash
54. Neisseria meningitidis (NM)
55. SR-A and Neisseria meningitidis
56. Uptake of NM is uncoupled from TNF production
57. Scavenger receptor A and NM
58. SR-A protects against NM
59. MARCO in a marker of activated macrophage
60. Binding of NM
61. Role of NM, INF-gamma in MARCO expression
62. Receptor collaboration
63. Plasma membrane in macrophage functions
64. EGF-TM7 family functions
65. Activatory and inhibitory receptor pairs
66. Macrophage fusion
67. Quantitation of macrophage fusion
68. Isolation of antibodies
69. Model of IL-4 induced macrophage fusion
70. Functional significance of macrophage fusion
71. Summary: macrophages in innate immunity
72. Thanks
73. References

Topics Covered

• Differentiation and distribution of macrophages
• The EGF-TM7 family
• Differentiation of monocytes
• Tropic interactions
• Monocyte recruitment
• Immune activation
• Monocyte heterogeneity
• Differential activation of macrophage
• Phagocytic pathway
• APC pattern recognition receptors
• APC receptors
• Macrophage receptors and interactions
• Dectin-1
• Mannose receptor
• MR ligands
• Scavenger receptors
• Neisseria Meningitidis
• Receptor collaboration
• Plasma membrane modulation of macrophage functions
• Activatory and inhibitory receptor pairs
• Macrophage fusion
• Isolation of antibodies

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009
• Archived on October 16, 2017

Financial Disclosures

• Siamon Gordon recieves Honoraria from Verseau Therapeutics and Myeloid Therapeutics. He has recieveid royalties from Thermo Fisher Scientific, and is involved in Bio-Rad sales.