• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. About the author
3. Chemotaxis
4. Chemokines and inflammation
5. Talk outline
6. Introduction to chemokine biology (1)
7. Introduction to chemokine biology (2)
8. The chemokine family
9. The structural motifs of the chemokine subfamilies
10. Introduction to chemokine biology - GAGs (1)
11. Introduction to chemokine biology - GAGs (2)
12. Chemokine receptors (1)
13. Chemokine receptors (2)
14. Chemokine receptors and their ligands
15. Decoy chemokine receptors (1)
16. Decoy chemokine receptors (2)
17. Chemokine evolution (1)
18. Chemokine evolution (2)
19. Phylogeny of the chemokine system
20. Homology of chemokine receptors
21. Development of chemotaxis systems
22. Use of chemotaxis systems
23. The role of chemokines in inflammation
24. What is inflammation?
25. Acute inflammation
26. Chronic inflammation
27. CXC family of chemokines and acute inflammation
28. CXC signaling in acute inflammation
29. CC chemokines and chronic inflammation
30. Chronic inflammatory diseases
31. Chemokines and leukocyte recruitment
32. Homeostatic chemokines
33. Chemokine function in atherosclerosis
34. Atherosclerosis plaque formation
35. Atherosclerosis plaque formation and chemokines
36. Evidence to chemokine function in atherosclerosis
37. Regulation of chemokines after endothelial damage
38. The role of chemokines after endothelial damage
39. The work of Saederup et al.
40. The role of chemokines in plaque formation
41. The role of chemokines in plaque progression (1)
42. The role of chemokines in plaque progression (2)
43. The role of T cells in plaque formation
44. The work of Mach et al. (1)
45. The work of Mach et al. (2)
46. The work of Mach et al. (3)
47. Chemokine ligand-receptor pairs in atherosclerosis
48. CCL2 acting via CCR2
49. Machrophage staining
50. Decreased lesion size in CCR2 -/- mice
51. Atherogenesis in LDL-R MCP-1 double knockout
52. Multiple roles for CCL2 in atherogenesis
53. CCL2 as a direct target for statin therapy
54. CCL3,4,5 acting via CCR1 and CCR5
55. CCL5 and CCR1
56. The role of CCR1 and CCR5 in atherosclerosis
57. CXCL9,10,11 acting via CXCR3
58. CXCL10 apoE double KO mice (1)
59. CXCL10 apoE double KO mice (2)
60. CX3CL1 acting via CX3CR2
61. CX3CL1 apoE double KO (1)
62. CX3CL1 apoE double KO (2)
63. CX3CL1 apoE double KO (3)
64. CX3CR1 polymorphisms and cardiovascular risk
65. Targeting chemokines in atherosclerosis
66. Strategies for targeting chemokines
67. Neutralizing antibodies
68. Anti-CCR2 monoclonal antibody - clinical trial
69. Small molecule inhibitors
70. Small molecule inhibitors - TAK-779 (1)
71. Small molecule inhibitors - TAK-779 (2)
72. Small molecule inhibitors - NBI-74330 (1)
73. Small molecule inhibitors - NBI-74330 (2)
74. Mutant chemokines
75. N terminal chemokine mutants
76. Met- RANTES
77. N terminal mutant of CCL2
78. Chemokine oligomerization mutants (1)
79. Chemokine oligomerization mutants (2)
80. Broad spectrum chemokine blockade
81. Expression of 35kDa chemokine binding protein (1)
82. Expression of 35kDa chemokine binding protein (2)
83. Long term CC chemokine inhibition (1)
84. Long term CC chemokine inhibition (2)
85. Conclusions and future prospects (1)
86. Conclusions and future prospects (2)
87. Conclusions and future prospects (3)
88. Conclusions and future prospects (4)
89. Thank you

Topics Covered

• Introduction to chemokine biology
• Chemokine receptors
• Decoy chemokine receptors
• Chemokine evolution
• Chemokine function
• Acute and chronic inflammation
• Chronic inflammatory diseases
• Chemokines and leukocyte recruitment
• Chemokine function in atherosclerosis
• CCL2 acting via CCR2
• CCL3, 4, 5 acting via CCR1 and CCR5
• CXCL9, 10, 11 acting via CXCR3
• CX3CL1 acting via CX3CR1
• Targeting chemokines in atherosclerosis and other forms of inflammation
• Neutralising antibodies
• Small molecule inhibitors
• Mutant chemokines
• Broad-spectrum chemokine blockade

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 30, 2009

Financial Disclosures

• Dr. David Greaves has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.