Registration for a live webinar on 'Precision medicine treatment for anticancer drug resistance' is now open.
See webinar detailsWe noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- About the author
- Chemotaxis
- Chemokines and inflammation
- Talk outline
- Introduction to chemokine biology (1)
- Introduction to chemokine biology (2)
- The chemokine family
- The structural motifs of the chemokine subfamilies
- Introduction to chemokine biology - GAGs (1)
- Introduction to chemokine biology - GAGs (2)
- Chemokine receptors (1)
- Chemokine receptors (2)
- Chemokine receptors and their ligands
- Decoy chemokine receptors (1)
- Decoy chemokine receptors (2)
- Chemokine evolution (1)
- Chemokine evolution (2)
- Phylogeny of the chemokine system
- Homology of chemokine receptors
- Development of chemotaxis systems
- Use of chemotaxis systems
- The role of chemokines in inflammation
- What is inflammation?
- Acute inflammation
- Chronic inflammation
- CXC family of chemokines and acute inflammation
- CXC signaling in acute inflammation
- CC chemokines and chronic inflammation
- Chronic inflammatory diseases
- Chemokines and leukocyte recruitment
- Homeostatic chemokines
- Chemokine function in atherosclerosis
- Atherosclerosis plaque formation
- Atherosclerosis plaque formation and chemokines
- Evidence to chemokine function in atherosclerosis
- Regulation of chemokines after endothelial damage
- The role of chemokines after endothelial damage
- The work of Saederup et al.
- The role of chemokines in plaque formation
- The role of chemokines in plaque progression (1)
- The role of chemokines in plaque progression (2)
- The role of T cells in plaque formation
- The work of Mach et al. (1)
- The work of Mach et al. (2)
- The work of Mach et al. (3)
- Chemokine ligand-receptor pairs in atherosclerosis
- CCL2 acting via CCR2
- Machrophage staining
- Decreased lesion size in CCR2 -/- mice
- Atherogenesis in LDL-R MCP-1 double knockout
- Multiple roles for CCL2 in atherogenesis
- CCL2 as a direct target for statin therapy
- CCL3,4,5 acting via CCR1 and CCR5
- CCL5 and CCR1
- The role of CCR1 and CCR5 in atherosclerosis
- CXCL9,10,11 acting via CXCR3
- CXCL10 apoE double KO mice (1)
- CXCL10 apoE double KO mice (2)
- CX3CL1 acting via CX3CR2
- CX3CL1 apoE double KO (1)
- CX3CL1 apoE double KO (2)
- CX3CL1 apoE double KO (3)
- CX3CR1 polymorphisms and cardiovascular risk
- Targeting chemokines in atherosclerosis
- Strategies for targeting chemokines
- Neutralizing antibodies
- Anti-CCR2 monoclonal antibody - clinical trial
- Small molecule inhibitors
- Small molecule inhibitors - TAK-779 (1)
- Small molecule inhibitors - TAK-779 (2)
- Small molecule inhibitors - NBI-74330 (1)
- Small molecule inhibitors - NBI-74330 (2)
- Mutant chemokines
- N terminal chemokine mutants
- Met- RANTES
- N terminal mutant of CCL2
- Chemokine oligomerization mutants (1)
- Chemokine oligomerization mutants (2)
- Broad spectrum chemokine blockade
- Expression of 35kDa chemokine binding protein (1)
- Expression of 35kDa chemokine binding protein (2)
- Long term CC chemokine inhibition (1)
- Long term CC chemokine inhibition (2)
- Conclusions and future prospects (1)
- Conclusions and future prospects (2)
- Conclusions and future prospects (3)
- Conclusions and future prospects (4)
- Thank you
Topics Covered
- Introduction to chemokine biology
- Chemokine receptors
- Decoy chemokine receptors
- Chemokine evolution
- Chemokine function
- Acute and chronic inflammation
- Chronic inflammatory diseases
- Chemokines and leukocyte recruitment
- Chemokine function in atherosclerosis
- CCL2 acting via CCR2
- CCL3, 4, 5 acting via CCR1 and CCR5
- CXCL9, 10, 11 acting via CXCR3
- CX3CL1 acting via CX3CR1
- Targeting chemokines in atherosclerosis and other forms of inflammation
- Neutralising antibodies
- Small molecule inhibitors
- Mutant chemokines
- Broad-spectrum chemokine blockade
Talk Citation
Greaves, D. (2009, June 30). Chemokines and inflammation: a critical assessment of therapeutic targets [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 12, 2024, from https://doi.org/10.69645/LMMM4738.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. David Greaves has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
Hide