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1. Introduction
2. About the author
3. Chemotaxis
4. Chemokines and inflammation
5. Talk outline
6. Introduction to chemokine biology (1)
7. Introduction to chemokine biology (2)
8. The chemokine family
9. The structural motifs of the chemokine subfamilies
10. Introduction to chemokine biology - GAGs (1)
11. Introduction to chemokine biology - GAGs (2)
12. Chemokine receptors (1)
13. Chemokine receptors (2)
14. Chemokine receptors and their ligands
15. Decoy chemokine receptors (1)
16. Decoy chemokine receptors (2)
17. Chemokine evolution (1)
18. Chemokine evolution (2)
19. Phylogeny of the chemokine system
20. Homology of chemokine receptors
21. Development of chemotaxis systems
22. Use of chemotaxis systems
23. The role of chemokines in inflammation
24. What is inflammation?
25. Acute inflammation
26. Chronic inflammation
27. CXC family of chemokines and acute inflammation
28. CXC signaling in acute inflammation
29. CC chemokines and chronic inflammation
30. Chronic inflammatory diseases
31. Chemokines and leukocyte recruitment
32. Homeostatic chemokines
33. Chemokine function in atherosclerosis
34. Atherosclerosis plaque formation
35. Atherosclerosis plaque formation and chemokines
36. Evidence to chemokine function in atherosclerosis
37. Regulation of chemokines after endothelial damage
38. The role of chemokines after endothelial damage
39. The work of Saederup et al.
40. The role of chemokines in plaque formation
41. The role of chemokines in plaque progression (1)
42. The role of chemokines in plaque progression (2)
43. The role of T cells in plaque formation
44. The work of Mach et al. (1)
45. The work of Mach et al. (2)
46. The work of Mach et al. (3)
47. Chemokine ligand-receptor pairs in atherosclerosis
48. CCL2 acting via CCR2
49. Machrophage staining
50. Decreased lesion size in CCR2 -/- mice
51. Atherogenesis in LDL-R MCP-1 double knockout
52. Multiple roles for CCL2 in atherogenesis
53. CCL2 as a direct target for statin therapy
54. CCL3,4,5 acting via CCR1 and CCR5
55. CCL5 and CCR1
56. The role of CCR1 and CCR5 in atherosclerosis
57. CXCL9,10,11 acting via CXCR3
58. CXCL10 apoE double KO mice (1)
59. CXCL10 apoE double KO mice (2)
60. CX3CL1 acting via CX3CR2
61. CX3CL1 apoE double KO (1)
62. CX3CL1 apoE double KO (2)
63. CX3CL1 apoE double KO (3)
64. CX3CR1 polymorphisms and cardiovascular risk
65. Targeting chemokines in atherosclerosis
66. Strategies for targeting chemokines
67. Neutralizing antibodies
68. Anti-CCR2 monoclonal antibody - clinical trial
69. Small molecule inhibitors
70. Small molecule inhibitors - TAK-779 (1)
71. Small molecule inhibitors - TAK-779 (2)
72. Small molecule inhibitors - NBI-74330 (1)
73. Small molecule inhibitors - NBI-74330 (2)
74. Mutant chemokines
75. N terminal chemokine mutants
76. Met- RANTES
77. N terminal mutant of CCL2
78. Chemokine oligomerization mutants (1)
79. Chemokine oligomerization mutants (2)
80. Broad spectrum chemokine blockade
81. Expression of 35kDa chemokine binding protein (1)
82. Expression of 35kDa chemokine binding protein (2)
83. Long term CC chemokine inhibition (1)
84. Long term CC chemokine inhibition (2)
85. Conclusions and future prospects (1)
86. Conclusions and future prospects (2)
87. Conclusions and future prospects (3)
88. Conclusions and future prospects (4)
89. Thank you

Topics Covered

• Introduction to chemokine biology
• Chemokine receptors
• Decoy chemokine receptors
• Chemokine evolution
• Chemokine function
• Acute and chronic inflammation
• Chronic inflammatory diseases
• Chemokines and leukocyte recruitment
• Chemokine function in atherosclerosis
• CCL2 acting via CCR2
• CCL3, 4, 5 acting via CCR1 and CCR5
• CXCL9, 10, 11 acting via CXCR3
• CX3CL1 acting via CX3CR1
• Targeting chemokines in atherosclerosis and other forms of inflammation
• Neutralising antibodies
• Small molecule inhibitors
• Mutant chemokines
• Broad-spectrum chemokine blockade

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Greaves, D. (2009, June 30). Chemokines and inflammation: a critical assessment of therapeutic targets [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved November 21, 2024, from https://doi.org/10.69645/LMMM4738.
Export Citation (RIS)

Publication History

• Published on June 30, 2009

Financial Disclosures

• Dr. David Greaves has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.