• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. The first attempt of intravital microscopy
3. Intravital microscopy
4. White cells in cremasteric venule
5. The leukocyte recruitment cascade (1)
6. Proposed mechanism for induced rolling
7. Role of P-selectin in leukocyte rolling
8. Selectins
9. Beta2 integrins (CD18)
10. LFA-1 and Mac-1 function (1)
11. LFA-1 and Mac-1 function (2)
12. Leukocyte recruitment cascade (2)
13. Adhesion of neutrophils is dependent on LFA-1
14. In vivo time lapse: leukocyte crawling
15. In vivo time lapse in Mac-1 deficient cells
16. Crawling is dependent on Mac-1
17. In vivo PECAM-labeled junctions
18. In vivo confocal microscopy
19. WT neutrophils transmigrate at junctions
20. Mac-1 deficiency effect on migration
21. Junctional migration
22. Mac-1 deficiency and neutrophils emigration time
23. Leukocyte recruitment cascade (3)
24. The liver vascular bed
25. Liver vascular bed - control
26. Vascular bed - an inflamed liver
27. Neutrophils and adhesion molecules in the liver
28. A role for adhesion in sinusoids?
29. Endothelial adhesion molecule expression in vivo
30. Adhesion molecule expression in various organs
31. Hyaluronan expression in the liver
32. CD44 is a receptor for HA
33. CD44 and HA mediate neutrophil adhesion
34. CD44 is not important in hepatic venules
35. Occlusion of sinusoids
36. CD44 and sinusoidal perfusion
37. Sinusoidal leukocyte adhesion is reversible
38. Reverse adhesion increases sinusoidal perfusion
39. Generation of Th1 and TH2 cells
40. Con A-induced liver inflammation
41. Multiple compartments for leukocyte recruitment
42. Vascular adhesion protein (VAP)-1 (1)
43. Vascular adhesion protein (VAP)-1 (2)
44. Hepatic VAP-1 expression
45. Th1 and Th2 lymphocyte adhesion
46. Alpha4 integrin mediates rolling and adhesion
47. Complete healing ileum
48. Clinical response to natalizumab
49. Brain preparation
50. Control brain
51. Inflamed brain
52. T cell-subset recruitment to the CNS in EAE
53. Mechanisms of Th1 T cell rolling
54. Mechanisms of Th2 T cell rolling
55. Th1 and Th2 cells bind P-selectin
56. Th1 and Th2 cells can bind selectins
57. Monitoring of blood vessels by monocytes
58. NKT cells in vascular bed of liver from CXCR6 mice
59. NKT cells from CXCR6 mice - enlarged video
60. The effect of systemic LPS on cell rolling
61. Rapid lung infiltration by neutrophils
62. Intravital microscopy of the lung
63. Leukocyte trafficking within the lung
64. The effect of systemic LPS on the lung
65. Neutrophils get stuck in the lung capillary
66. Which molecules mediate neutrophil recruitment?
67. How do neutrophils enter lungs?
68. Neutrophils are activated in endotoxemic blood
69. Scheme of the effect of LPS
70. Both leukocytes and endothelium respond to LPS
71. Bone marrow transfer protocol
72. Bone marrow transfer experiment
73. LPS effect on TLR4 leukocytes
74. Systemic LPS and leukocyte activation
75. Candidates for neutrophil recruitment
76. Acknowledgements

Topics Covered

• Leukocyte recruitmen
• A multi-step recruitment that involves rolling adhesion, crawling to junctions and emigration
• Role of selectins and integrin subunits in this process
• Role for other adhesion molecules in liver, lung and potentially other organs
• Constitutive patrolling of immune cells in various tissues
• Role for sentinel cells such as endothelium, mast cells and macrophage in inducing recruitment into tissues

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 30, 2009

Financial Disclosures

• Prof. Paul Kubes has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.