• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani from humanitas.it
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani from humanitas.it
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Mononuclear phagocyte system
3. Macrophages.com website
4. Image from macrophages.com
5. Localization of macrophages in tissues
6. Marker for the mononuclear phagocyte system
7. EGFP expression in all MacGreen macrophages
8. The MacGreen mouse: possible applications
9. Intravital imaging of MacGreen mouse hind joint
10. Macrophages and bone
11. Using MacGreen to study macrophages in bone
12. Distribution of BAMs on bone surface
13. Macrophages in blood vessels of MacGreen
14. Binary expression system using CSF-1R promoter
15. The binary system is functional in macrophages
16. Using MacBlue to study tissue remodeling
17. ECFP expression in microglia of MacBlue mice
18. Expression of a tagged Schlafen4 in primary cells
19. Cellular systems biology
20. The FANTOM consortium
21. CAGE technology
22. TAG clusters identify TSS and promoters
23. CAGE is a form of expression profiling
24. Macrophage-specific promoters and their biology
25. Biology of gelsolin
26. Two major promoters in the gelsolin locus
27. The two promoters lead to two forms of gelsolin
28. Gelsolin promoter 2: lung-enriched
29. Conservation of promoter 2 in mouse and human
30. Promoter 1: macrophage-enriched, broad type
31. Conservation of promoter 1 in mouse and human
32. What do we learn from gelsolin?
33. Gelsolin-related protein (CapG) is also complex
34. Using promoter analysis to study IGF-1
35. Expression patterns: macrophage vs. osteoblast
36. The complicated IGF-1 promoter region
37. IGF-1 promoter conservation across species
38. CSF-1 deficient animal is also IGF-1 deficient
39. THP-1: a model for cellular differentiation
40. THP-1: PMA differentiation time-course
41. PMA induces macrophage markers
42. PU1- one gene, three promoters
43. Integrating data from THP-1 differentiation analysis
44. Motif activity analysis
45. Example of a network of transcription factors
46. So, what does it all mean?
47. Credits

Topics Covered

• Marker for the mononuclear phagocyte system
• CSF-1R
• EGFP
• The MacGreen mouse
• Macrophages and bone
• MacBlue mice
• Association of macrophages with tissue remodelling during embryonic development
• Cellular systems biology
• Transcriptional landscape of the mammalian genome
• CAGE technology
• Expression profiling
• Macrophage-specific promoters and their associated biology
• Biology of Gelsolin
• Gelsolin-related protein
• IGF-1 promoter region
• THP-1: a model for cellular differentiation
• PMA induces macrophage markers
• Motif activity analysis

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on June 30, 2009
• Reviewed on July 23, 2020

Financial Disclosures

• Prof. David Hume has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.