• Models of Investigation
• 41 min
  1. Antifungal innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 44 min
  2. The anti-microbial defense of Drosophila: a paradigm for innate immunity

  • Prof. Jules Hoffmann
• 38 min
  3. Phagocytosis in the fruit fly, Drosophila melanogaster

  • Dr. Lynda Stuart
• 62 min
  4. Innate immune sensing and response

  • Prof. Bruce Beutler
• 61 min
  5. Macrophages and systems biology

  • Prof. David Hume
• Cell Types and Recruitment
• 71 min
  6. Leukocyte recruitment in vivo

  • Prof. Paul Kubes
• 51 min
  7. Chemokines and inflammation: a critical assessment of therapeutic targets

  • Dr. David Greaves
• 42 min
  8. Eosinophils

  • Prof. Tim Williams
• 63 min
  9. Dendritic cells: linking innate to different forms of adaptive immunity

  • Prof. Ralph Steinman
• 25 min
  10. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmunity

  • Prof. Yong-Jun Liu
• 61 min
  11. Innate-like lymphocytes 1

  • Prof. Adrian Hayday
• 41 min
  12. Innate-like lymphocytes 2

  • Prof. Adrian Hayday
• Recognition and Signaling
• 50 min
  13. Colony stimulating factor-1 regulation of macrophages in development and disease

  • Prof. E. Richard Stanley
• 42 min
  14. Fc receptors: linking innate and acquired immunity

  • Prof. Ken G C Smith
• 39 min
  15. Phagocytosis

  • Prof. Joel Swanson
• 44 min
  16. Clearance of apoptotic cells and the control of inflammation

  • Prof. Sir John Savill
• 38 min
  17. Signaling by innate immune receptors

  • Prof. Michael Karin
• 41 min
  18. Nuclear receptors at the crossroads of inflammation and atherosclerosis

  • Prof. Christopher Glass
• Modulation of Effector Responses
• 22 min
  19. Humoral innate immunity and the acute phase response 1

  • Prof. Alberto Mantovani
• 42 min
  20. Humoral innate immunity and the acute phase response 2

  • Prof. Alberto Mantovani
• 54 min
  21. Cytokines regulating the innate response

  • Prof. Anne O’Garra
• 39 min
  22. Arginase and nitric oxide

  • Dr. Peter Murray
• 38 min
  23. Novel lipid mediators in resolution of inflammation

  • Prof. Charles Serhan
• 69 min
  24. Resolvins activate inflammation-resolution programs: a systems approach to resolution

  • Prof. Charles Serhan
• 42 min
  25. Cationic peptides in innate immunity

  • Dr. Dawn Bowdish
• 27 min
  26. Iron metabolism and innate immunity

  • Prof. Tomas Ganz
• Pathogen-Host Interactions
• 46 min
  27. Innate recognition of viruses

  • Prof. Caetano Reis e Sousa
• 50 min
  28. Type I interferons in innate immunity to viral infections

  • Prof. Christine Biron
• 56 min
  29. HIV-1 and immunopathogenesis: innate immunity

  • Prof. Luis Montaner
• 53 min
  30. Understanding and combating tuberculosis

  • Prof. David Russell
• 34 min
  31. The taste of a fungus: recognition of Candida by the innate immune system

  • Prof. Neil Gow
• 51 min
  32. Innate immunity and malaria

  • Prof. Douglas Golenbock
• Health and Disease
• 39 min
  33. Innate immunity in children

  • Prof. David Speert
• 59 min
  34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis

  • Prof. Sir Ravinder Maini
• 33 min
  35. NOD-like receptors in innate immunity and inflammatory disease

  • Prof. Gabriel Nunez
• 38 min
  36. Paneth cells in innate immunity and inflammatory bowel disease

  • Prof. Satish Keshav
• 36 min
  37. Innate immunity in the brain in health and disease

  • Prof. V. Hugh Perry
• 54 min
  38. The fate of monocytes in atherosclerosis

  • Prof. Gwendolyn Randolph
• 49 min
  39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis

  • Prof. Jeffrey Pollard
• Archived Lectures *These may not cover the latest advances in the field
• 73 min
  40. Monocyte/macrophages in innate immunity

  • Prof. Emeritus Siamon Gordon
• 32 min
  41. Innate immunity in C. elegans

  • Dr. Jonathan Ewbank
• 51 min
  42. Antigen processing and presentation: modulation by innate immune signals

  • Prof. Colin Watts
• 39 min
  43. NLR genes: infection, inflammation and vaccines

  • Prof. Jenny Ting
• 63 min
  44. Manipulation of innate immune response: lessons from shigella

  • Prof. Philippe Sansonetti
• 35 min
  45. Innate immunity of the lung and adaptation to air breathing at birth

  • Prof. Jeffrey Whitsett

Printable Handouts

PDF

Navigable Slide Index

1. Introduction
2. Innate immune sensing and response
3. How do we know when we have an infection?
4. The Pfeiffer phenomenon
5. LPS is an activator of innate immune response
6. Biological phenomenon
7. The C3H/HeJ mouse and the Lps locus
8. C3H/HeJ mice have a missense mutation of Tlr4
9. The "Dorsal group" in drosophila (1)
10. The "Dorsal group" in drosophila (2)
11. Chronology
12. TLR family
13. Signaling by the TLR family (1)
14. Signaling by the TLR family (2)
15. Forward genetics with ENU
16. Snowflake
17. Velvet
18. Piglet
19. Eel
20. Business class
21. Mask
22. Results to date
23. Positional cloning no longer requires fine mapping
24. Positional cloning scheme
25. A search for TLR signaling defects
26. This has led to these identifications
27. MyD88 independent signaling pathway
28. Mutations in the TLR signaling pathway
29. Spin phenotype (1)
30. Spin phenotype (2)
31. Spin macrophages produce normal amount of TNF
32. A Myd88 mutation fully suppress spin phenotype
33. Spin homozygotes develop autoimmunity
34. Germfree environment suppress autoimmunity
35. Spin is a missense allele of Ptpn6
36. Finding the role of SHP1 phosphatase (1)
37. Finding the role of SHP1 phosphatase (1)
38. Sensing is necessary but not the whole story
39. MCMV dose: lethality relationship over time
40. How many genes make a life-or-death difference
41. MCMV resistance: pathways for survival
42. Grey mutant mice
43. Genes involved in MCMV resistance (1)
44. MCMV-induced cytokines peak timings
45. Viral titres of Mayday mutants infected with MCMV
46. MayDay is hypersensitive to LPS
47. MayDay respond normally to TLR agonists
48. MayDay mutation is mapped to chromosome 6
49. 2 candidate genes in the MayDay critical region
50. The transmembrane topology of SUR2 and Kir6.1
51. Absence of Kir6.1 transcripts in MayDay mutants
52. LPS-perturbed gene expression in MayDay mice
53. Cardiac ischemia in Kir6.1-KO mice
54. dSUR plays a protective role against FHV
55. Linking endotoxemia to vasoconstriction
56. What causes the lethal effect of LPS in MayDay?
57. Genes involved in MCMV resistance (2)
58. Additional mutations
59. Some points about innate immunity

Topics Covered

• Sensing infection is essential to the initiation of an immune response
• The innate immune system senses signature molecules made by microbes using a conserved set of germline-encoded receptors
• This receptor family (the Toll-like receptors) was first understood when a mutation that abolished lipopolysaccharide (LPS) sensing was positionally cloned in mice
• In Drosophila a homologous receptor is also used to detect infection, and still another receptor activates a pathway evocative of the tumor necrosis factor (TNF) pathway in mammals
• Further work in mammals has depended upon gene targeting and also forward genetic work, which has revealed many of the components of the TLR signaling apparatus
• Forward genetics has also allowed us to see how many genes (and what kinds of genes) are important for resisting an infection in vivo

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Bruce Beutler has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.