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1. Introduction
2. Insects are prone to many types of infections
3. Insect host defense is a multifacetted process
4. Induction of antimicrobial activity
5. Systemic antimicrobial response in Drosophila
6. NF-kappaB-response elements in Drosophila
7. Two types of NF-kappaB family members
8. Gene cascade controlling the dorso-ventral axis
9. Toll controls drosomycin but not diptericin
10. Imd mutants are sensitive to bacterial infections
11. Toll mutants are sensitive to fungal infections
12. Overwhelming fungal infection in a Toll mutant
13. Toll as an IL-1R and CD-14 chimera
14. TLR family members and their ligands
15. NF-kappaB activation in Drosophila
16. Semmelweis and anti-gram-positive defense
17. Structural aspects of PGRPs
18. Peptidoglycan and the roles of PGRPs
19. Immune responses to different pathogens
20. NF-kappaB activation by Toll in Drosophila
21. NF-kappaB activation by IMD in Drosophila
22. The response of Drosophila to virus infection
23. Drosophila responses to RNA virus infections (1)
24. Drosophila responses to RNA virus infections(2)
25. Role of the mosquito immune system
26. Levels of Plasmodium in A. gambiae
27. The immune response can kill the Plasmodium
28. Cactus depletion aborts Plasmodium development
29. Plasmodium abortion rescued by Rel1 knockdown
30. Thioester-containing protein 1 in A. gambiae
31. Parasite survival in TEP1 transgenic mosquitoes
32. Phylogeny of NF-kappaB
33. Signaling cascades: Drosophila and mammals
34. Acknowledgements
35. Credits: Drosophila immunity

Topics Covered

• The insect host defense is a multifaceted process
• Systemic anti-microbial response in Drosophila
• NF-kB: a central transactivator in immune responses
• Gene cascade
• The Toll pathway
• Imd pathway mutants are sensitive to bacterial infections
• Toll pathway mutants are sensitive to fungal infections
• TLR family members and their ligands
• The semmelweis (seml) mutation compromises the anti-gram-positive defense
• Structural aspects of PGRPs
• NF-kB activation by Toll and IMD in Drosophila
• Investigating the response of Drosophila to virus infection
• Response to RNA virus infections
• Keeping parasite numbers low: role of the mosquito immune system
• Losses and amplification of Plasmodium in A. gambiae
• Cactus
• ThioEster-containing Protein 1 (TEP1)

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Infectious Diseases

Talk Citation

Hoffmann, J. (2009, May 31). The anti-microbial defense of Drosophila: a paradigm for innate immunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 15, 2025, from https://doi.org/10.69645/GTQX5927.
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Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. Jules Hoffmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.