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- Models of Investigation
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41 min
1. Antifungal innate immunity in C. elegans- Dr. Jonathan Ewbank
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44 min
2. The anti-microbial defense of Drosophila: a paradigm for innate immunity- Prof. Jules Hoffmann
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38 min
3. Phagocytosis in the fruit fly, Drosophila melanogaster- Dr. Lynda Stuart
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62 min
4. Innate immune sensing and response- Prof. Bruce Beutler
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61 min
5. Macrophages and systems biology- Prof. David Hume
- Cell Types and Recruitment
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71 min
6. Leukocyte recruitment in vivo- Prof. Paul Kubes
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51 min
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42 min
8. Eosinophils- Prof. Tim Williams
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63 min
9. Dendritic cells: linking innate to different forms of adaptive immunity- Prof. Ralph Steinman
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25 min
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61 min
11. Innate-like lymphocytes 1- Prof. Adrian Hayday
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41 min
12. Innate-like lymphocytes 2- Prof. Adrian Hayday
- Recognition and Signaling
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50 min
13. Colony stimulating factor-1 regulation of macrophages in development and disease- Prof. E. Richard Stanley
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42 min
14. Fc receptors: linking innate and acquired immunity- Prof. Ken G C Smith
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39 min
15. Phagocytosis- Prof. Joel Swanson
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44 min
16. Clearance of apoptotic cells and the control of inflammation- Prof. Sir John Savill
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38 min
17. Signaling by innate immune receptors- Prof. Michael Karin
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41 min
18. Nuclear receptors at the crossroads of inflammation and atherosclerosis- Prof. Christopher Glass
- Modulation of Effector Responses
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22 min
19. Humoral innate immunity and the acute phase response 1- Prof. Alberto Mantovani
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42 min
20. Humoral innate immunity and the acute phase response 2- Prof. Alberto Mantovani
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54 min
21. Cytokines regulating the innate response- Prof. Anne O’Garra
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39 min
22. Arginase and nitric oxide- Dr. Peter Murray
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38 min
23. Novel lipid mediators in resolution of inflammation- Prof. Charles Serhan
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69 min
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42 min
25. Cationic peptides in innate immunity- Dr. Dawn Bowdish
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27 min
26. Iron metabolism and innate immunity- Prof. Tomas Ganz
- Pathogen-Host Interactions
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46 min
27. Innate recognition of viruses- Prof. Caetano Reis e Sousa
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50 min
28. Type I interferons in innate immunity to viral infections- Prof. Christine Biron
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56 min
29. HIV-1 and immunopathogenesis: innate immunity- Prof. Luis Montaner
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53 min
30. Understanding and combating tuberculosis- Prof. David Russell
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34 min
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51 min
32. Innate immunity and malaria- Prof. Douglas Golenbock
- Health and Disease
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39 min
33. Innate immunity in children- Prof. David Speert
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59 min
34. From bench to bedside: evolution of anti-TNFalpha therapy in rheumatoid arthritis- Prof. Sir Ravinder Maini
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33 min
35. NOD-like receptors in innate immunity and inflammatory disease- Prof. Gabriel Nunez
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38 min
36. Paneth cells in innate immunity and inflammatory bowel disease- Prof. Satish Keshav
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36 min
37. Innate immunity in the brain in health and disease- Prof. V. Hugh Perry
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54 min
38. The fate of monocytes in atherosclerosis- Prof. Gwendolyn Randolph
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49 min
39. Macrophages, a cellular toolbox used by tumors to promote progression and metastasis- Prof. Jeffrey Pollard
- Archived Lectures *These may not cover the latest advances in the field
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73 min
40. Monocyte/macrophages in innate immunity- Prof. Emeritus Siamon Gordon
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32 min
41. Innate immunity in C. elegans- Dr. Jonathan Ewbank
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51 min
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39 min
43. NLR genes: infection, inflammation and vaccines- Prof. Jenny Ting
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63 min
44. Manipulation of innate immune response: lessons from shigella- Prof. Philippe Sansonetti
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35 min
45. Innate immunity of the lung and adaptation to air breathing at birth- Prof. Jeffrey Whitsett
Printable Handouts
Navigable Slide Index
- Introduction
- C. elegans - structure
- C. elegans - inner structure
- Why C. elegans? physical properties
- Life cycle of C. elegans
- Why C. elegans? genetic aspects
- Micro-injection of C. elegans
- Transgenic C. elegans
- Why C. elegans? advantages as genetic model
- Growing method of C. elegans in the lab
- C. elegans in the natural environment
- The dauer stage
- A dauer pheromone
- Pheromones
- Attraction of males by hermaphrodites
- C. elegans is attracted by bacteria
- C. elegans prefers S. marcescens
- Worms are repelled by S. marcescens
- Worms are not repelled by SM267
- SM267 does not make serrawettin W2
- Implications of the detection mechanism
- C. elegans eats bacteria
- The grinder
- E. coli is broken down in the pharynx
- S. marcescens destrys the grinder
- Infection by S. marcescens
- Response to P. luminescens & Db11
- Host response to infection is specific
- Response specificity - live vs. dead bacteria
- Response specificity - virulence
- Response specificity - virulence and viability (1)
- Response specificity - virulence and viability (2)
- Response specificity - bacteria strain
- Response to infection - a common signature
- EASE with the common response genes
- Infection by P. luminescens - necrotic reporter
- Regulation of necrosis
- Suppression of necrosis
- D. coniospora spores
- Infection of C. elegans by D. coniospora
- nlp and cnc genes are highly up-regulated
- Phylogenetic analysis of nlp and cnc genes
- nlp clusters in three Caenorhabditis species
- nlp cluster in C. elegans
- Over-expression of nlp and resistance
- Epidermal expression of AMP genes
- Induction of nlp-29 after Drechmeria infection
- Induction of pnlp-29::GFP
- Induction of nlp-29
- No induction of nlp-29
- D. coniospora penetrates the cuticle
- Physical injury of C. elegans
- Physical injury triggers wound repair
- Physical injury induces pnlp-29::GFP
- Abnormal epithelial cell development
- Osmotic shock induces pnlp-29::GFP
- AMP gene expression in Drosophila
- Rel homology domain proteins
- TIR domain proteins
- A TIR domain adaptor protein in C. elegans
- p38 MAPK pathway involved in defence
- dapk-1 mutants have a wounded epidermis
- AMP genes are upregulated in dapk-1 mutants
- DAPK is a negative regulator of AMP expression
- A suppressor of the epidermal defects
- Two roles for DAPK
- Open questions
- The nipi mutants (1)
- An example of a nipi mutant
- The nipi mutants (2)
- nipi-1 = PKCdelta
- PKC-delta activation
- Induction by PMA
- G-protein/PKC upstream of the p38 pathway
- nipi-3 affects transcriptional response to infection
- Two signals in response to infection
- Sodium-neurotransmitter symporter family (1)
- Sodium-neurotransmitter symporter family (2)
- Sodium-neurotransmitter symporter family (3)
- Interaction with a STAT like transcription factor
- Physical interaction - SNF-12 and STA-2
- sta-2 is required for nlp-29 induction
- AMP gene regulation in C. elegans
- Conclusions
- Thanks to our collaborators
- The lab members
Topics Covered
- Anatomy of C. elegans
- C. elegans as an experimental animal
- Pheromone signalling and pathogen detection
- Specific and general transcriptional responses to bacterial infection
- Necrosis
- Fungal infection and injury induce antimicrobial peptide genes
- Signal transduction pathways that control antimicrobial peptide gene expression
Talk Citation
Ewbank, J. (2011, November 3). Innate immunity in C. elegans [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 20, 2024, from https://hstalks.com/bs/1278/.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Jonathan Ewbank has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
