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Printable Handouts
Navigable Slide Index
- Introduction
- Overview
- Toxic metals in the environment
- Arsenic as an environmental contaminant
- Arsenic as a causative agent in disease
- Arsenic contamination in New England
- Arsenic microarray - one-color
- Effects of metals on gene expression
- Effects of arsenic on gene expression
- Daphnia pulex microarrays as a model
- Analysis of Daphnia pulex results
- Arsenic effects on Daphnia genes
- Comparison of SAM and QED analysis
- Non-parametric gene expression
- Rank product analysis of microarrays
- Parametric method limitations
- Long gene lists - how long?
- Individual genes vs. patterns
- Canonical pathway analysis
- Non-canonical networks of genes
- Arsenic effects in mouse lung
- Arsenic effects in lung - doses
- Arsenic effects in lung - heat map
- Arsenic effects in cells - doses
- Phenotypic switching by arsenic
- Effects of diet on gene expression
- Arsenic as an Endocrine Disruptor
- Arsenic disruption of GR in vivo
- Arsenic effects on IL1B network
- Arsenic effects on TLR signaling
- Summary of statistical methods
- Summary of arsenic effects
- Acknowledgements
Topics Covered
- Arsenic as an environmental chemical of concern for human health
- Use of microarrays to understand patterns of gene expression changes in response to low levels of toxic metals
- Development of non-parametric techniques for evaluating results of microarrays
- Use of patterns and biological pathways to understand microarray results
- Microarray analysis of low dose arsenic effects
Talk Citation
Hamilton, J. (2009, March 30). The use of microarrays to understand the biology and toxicology of low dose arsenic [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 6, 2024, from https://doi.org/10.69645/PVGR4110.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Joshua Hamilton has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
The use of microarrays to understand the biology and toxicology of low dose arsenic
A selection of talks on Methods
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