MicroarraysTheir design and use

Launched March 2009 Updated September 2009 13 lectures
Prof. Craig R. Tomlinson
Dartmouth Hitchcock Medical Center, Dartmouth College, USA
Summary

Genomics is defined as the determination of the sequence, location and annotation of the genes in a genome. Functional genomics is the study of how a particular genotype gives rise to a particular phenotype, and the primary method to carry out functional genomics studies is by using microarrays. The overriding... read moreutility of microarrays is that all genes, as well as the entire genome, can be characterized simultaneously in parallel. Thus, high-throughput approaches are being employed in broad and diverse areas of research, including the probing of basic cell biology questions as to how genes differ and are differentially expressed, diagnosis and prognosis of disease, evolution of genes and gene expression, pathology and forensic applications, drug discovery and development, identification of drug targets in pharmacogenomics, and many other areas.