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Printable Handouts
Navigable Slide Index
- Introduction
- Regulation of gene expression
- Eukaryotic gene expression
- Translational control of gene expression
- Genome-wide analysis of gene translation
- Total RNA vs. polysome-bound RNA
- Sucrose gradient fractionation of cytosol
- Cell radioresponse
- Radiation induced gene expression
- The effect of radiation through the 2 approaches
- Radiation modulated genes
- Transcription vs. translation
- Hypothesis regarding the effect of radiation
- Radiation and polysomal mRNA distribution
- Proteins predicted to increase after irradiation
- Proteins predicted to decrease after irradiation
- GOstat
- Ingenuity pathway analysis (IPA)
- Radiation induced changes: glioma comparison
- GOstat: glioma comparison
- IPA: glioma comparison
- Radiation induced gene expression: summary
- Radiation effect vs. tissue of origin
- Genes affected by 2Gy vs. cell line
- Genes commonly affected in cells lines
- Genes common to each tumor type
- Commonly affected genes: tumor vs. normal
- Cancer vs. normal cells: biological networks
- Top ranked network in tumor cells
- Top ranked network in normal cells
- Radiation induced translational profiles
- Summary
- Acknowledgments
- References
Topics Covered
- Radiation-induced gene expression has long been considered to play a role in determining cellular radioresponse
- Analyses of single genes and whole genomes indicate that radiation-induced changes at the mRNA level do not correlate with changes in corresponding proteins
- Microarray analysis of polysome-bound RNA indicates that radiation modifies the translational activity of mRNA subpopulations, which correlates with protein products
- Gene translation is considerably more susceptible to radiation-induced changes than is the transcriptome
- Defining the genes whose translation is modified by radiation may provide an approach for identifying critical proteins and pathways that serve as determinants of radiosensitivity
Talk Citation
Tofilon, P. (2009, March 30). Global analysis of gene translation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved December 3, 2024, from https://doi.org/10.69645/RDMD3482.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Philip Tofilon has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.