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FRED GUENGERICH: Hello, my
name is Dr. Fred Guengerich.
I'm at Vanderbilt University in
Nashville, Tennessee in the United States.
And today I'd like to
talk to you about cytochrome P450,
specifically the cytochrome P450
1 family and the roles of cytochromes
P450 1A1, 1A2, and
1B1 in the metabolism
of drugs and other things.
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So what I'd like to do today
is talk about first of all
some background on cytochrome P450.
Most of my slides will use
the abbreviation, P450.
Some may use the CYP, which is
an acronym for cytochrome P450.
And I also talk about the
relevance to human health.
I am going to give you some
background on the P450 family 1
and some important concepts
from the literature;
particularly in
terms of localization
and the three-dimensional
structures of these enzymes
and their relevance to a function.
I'm going to talk
about more research
on these particular
P450s, the roles of family 1
P450s in the metabolism
of carcinogens.
I'll talk about induction and
inhibition, the significance
of genetic variations,
and also a little bit
about heterocyclic amines and
the possible risk from cancer.
1:30
So let's talk generally
about cytochrome P450s
and drugs and diseases.
In the human genome, we know
that there are exactly 57
cytochrome P450 genes and proteins.
Most of these are involved
in the metabolism of steroids
and other endogenous compounds,
but 15 of these at least
are involved in the
metabolism of drugs
and other xenobiotic chemicals.
Xenobiotic is a term
that we use to describe
compounds, chemicals that is,
that are not normally in the body.
For instance, drugs,
pesticides, things like this
would be in this regard.
