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1. Introduction
2. Outline
3. Definition of an adaptive clinical trial
4. FDA: guidance for adaptive design clinical trials
5. Frequentist vs. Bayesian vs. likelihood
6. Three major branches of the statistics
7. Frequentist vs. Bayesian
8. Example of an adaptive clinical trials design
9. Goals of phase II oncology trials
10. Important design considerations in phase II trials
11. Standard single arm phase II study
12. Two-stage designs
13. Revised design
14. Simon two-stage design
15. Balanced design
16. Gehan and Fleming two-stage design
17. Frequentist versus Bayesians
18. Bayesian inference
19. Bayesian Designs
20. Bayesian design example (N=0)
21. Bayesian design example (N=1)
22. Bayesian design example (N=2)
23. Bayesian design example (N=4)
24. Bayesian design example (N=5)
25. Bayesian design example (N=39)
26. Posterior probabilities
27. Other priors

Topics Covered

• Definition of an adaptive clinical trial
• FDA: guidance for adaptive design clinical trials
• Frequentist vs. Bayesian vs. likelihood
• Three major branches of the statistics
• Example of an adaptive clinical trials design
• Two-stage designs
• Revised design
• Simon two-stage design
• Balanced design
• Gehan and Fleming two-stage design

Links

Series:

• Adaptive Clinical Trial Design

Categories:

• Methods
• Pharmaceutical Sciences

Talk Citation

Publication History

• Published on August 31, 2017

Financial Disclosures

• Professor Yu Shyr has no commercial/financial relationships to disclose