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1. Introduction
2. The lung and the environment
3. The alveoli
4. Environmental stress
5. The alveolar macrophage
6. Alveolar macrophages (1)
7. Bone marrow-derived cells
8. Bronchoalveolar lavage
9. Alveolar macrophages (2)
10. Turnover of alveolar macrophages
11. Normal functions of the alveolar macrophage
12. Alveolar macrophages and host defenses (1)
13. Alveolar macrophages and host defenses (2)
14. Alveolar macrophages and host defenses (3)
15. Alveolar macrophages and collateral damage
16. Alveolar macrophages and disease
17. Alveolar macrophages and lung infection
18. Emphysema associated with HIV1+ smokers
19. MMP expression in HIV1+ smokers
20. MMP-1 levels in macrophages of HIV1+ individuals
21. Up-regulated macrophage MMP gene expression
22. Idiopathic pulmonary fibrosis
23. Clinical features
24. Alveolar macrophages photo micrograph
25. Pathogenesis of the injury to the lung
26. Macrophages and idiopathic pulmonary fibrosis
27. Pulmonary alveolar proteinosis (1)
28. Pulmonary alveolar proteinosis (2)
29. Smoking-associated lung disease (1)
30. Smoking and alveolar macrophages
31. Cigarette smoking: changes in DNA methylation
32. Alveolar macrophage transcriptome in smokers
33. Study populations
34. Macrophage genome-wide gene expression
35. Gene expression comparison (1)
36. Gene expression comparison (2)
37. Gene expression comparison (3)
38. Response variability of macrophages to smoking?
39. Quantifying the extent of up- and down-regulation
40. Index-AM
41. Alveolar macrophage transcriptome
42. Macrophage polarization programs
43. M1 and M2 polarization
44. M1 gene signature
45. M2 gene signature
46. Smoking-associated lung disease (2)
47. Smoking & polarization programs of macrophages
48. Nonsupervised hierarchical cluster analysis
49. Comparison of M1 program suppression in AM
50. M1-and M2-related protein expression: FACS
51. M1 deactivation / partial M2-like reprogramming
52. Polarization programs & development of COPD
53. Reciprocal alteration of gene expression & COPD
54. Smoking-induced modification of AM transcriptome
55. Summary

Topics Covered

• Environmental stress and the lung
• Disorders and diseases of the lung
• Gene expression of macrophages
• Macrophage polarisation programs
• Smoking and alveolar macrophages

Links

Series:

• Macrophage Heterogeneity and Function

Categories:

• Biochemistry
• Cell Biology
• Immunology

Therapeutic Areas:

• Immunology & Inflammation
• Respiratory Diseases

Talk Citation

Publication History

• Published on February 13, 2013
• Reviewed on January 23, 2022

Financial Disclosures

• Dr. Ronald G. Crystal has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.