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Printable Handouts
Navigable Slide Index
- Introduction
- Ilya Mechnikov
- Host-mediated detection of microbes
- The nod-like receptor family
- Nod1 and Nod2
- Nod1 is a sensor for a peptidoglycan (1)
- Nod1 is a sensor for a peptidoglycan (2)
- Nod1 is a sensor for a peptidoglycan (3)
- Nod2 is a sensor for a peptidoglycan
- Nod1 & Nod2 recognize bacterial peptidoglycan
- Role of Nod1 in infected intestinal epithelial cells
- Nod1 and Nod2 are intracellular PRMs
- How Nod ligands get access to host cytosol
- Muramyl peptides - activity requires internalization
- Nod1 ligands: structure and activity (1)
- Nod1 ligands: structure and activity (2)
- Nod1 ligands escape the endocytic pathway
- Model - how Nod ligands enter the host cytosol
- SLC15A4 is a transporter for Nod1 ligands
- Upregulation of SLC15A4 in disease
- Nod2 and Crohn's disease
- Nod-like receptor & auto-inflammatory disorders
- Expression of functional Nod2 in epithelial cells
- The 3020insC frame-shift mutation of Nod2 (1)
- The 3020insC frame-shift mutation of Nod2 (2)
- Other Crohn's disease associated Nod2 mutations
- Models explaining the Nod2 loss & CD paradox
- Loss of antimicrobial activity
- MDP triggers antimicrobial peptide secretion
- Defective induction of defensins
- Decreased production of NO
- Production of antimicrobial ROS
- Nod2 mutation in CD-gain of function mutation (1)
- Nod2 mutation in CD-gain of function mutation (2)
- Negative regulation of Th1 responses by Nod2
- Defective Nod2 targeting to plasma membrane
- Defective polarization of Th2 immune responses
- More recent models - autophagy
- ATG16L1 and Crohn's disease (1)
- ATG16L1 and Crohn's disease (2)
- ATG16L1 and Crohn's disease (3)
- Bacterial autophagy
- Nod2fs cells fail to direct autophagy
- Nod2 brings ATG16L1 to the membrane
- Nod1/Nod2 direct autophagy to bacterial entry site
- More recent models- the IL-17/IL-22 axis
- Delayed histopathology in Nod1/2 DKO mice
- Early IL-17 responses are Nod1/2 dependent (1)
- Early IL-17 responses are Nod1/2 dependent (2)
- Specific cells produce IL-17/22 early
- Lack of early Th17 response NOD1/2 KNO mice
- Working model
- General conclusions
Topics Covered
- Innate immunity
- Host detection of intracellular bacterial pathogens by Nod-like receptors
- Dysregulation of intestinal immune control of bacteria
- Crohn's disease
Talk Citation
Girardin, S. (2011, September 27). Nod proteins in mucosal defense against bacteria: implications for Crohn's disease [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 15, 2024, from https://doi.org/10.69645/LOME2381.Export Citation (RIS)
Publication History
Financial Disclosures
- Dr. Stephen Girardin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.
A selection of talks on Clinical Practice
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