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Printable Handouts
Navigable Slide Index
- Introduction
- Outline
- Apoptotic cell clearance deficiency
- Apoptotic and necrotic cell death
- Apoptotic cell death during development
- The balance of life and death
- Inducers of apoptosis
- Apoptosis vs. primary necrosis
- The sites of apoptosis
- Exposure during apoptosis of phosphatidylserine
- Exposure of phosphatidylserine on viable cells
- Oxidation of phosphatidylserine
- Cyt c as a catalyst for selective oxidation of PS
- Inflammatory molecules in activated cells
- Inflammatory molecules in early apoptotic cells
- Inflammatory molecules in late apoptotic cells
- Inflammatory molecules in necrotic cells
- Summary on inflammatory molecules in apoptosis
- Clearance of dying cells
- Communication network of apoptosis
- Apoptotic cell - immune reaction/tolerance
- Necrotic cell - immune reaction/tolerance
- PS molecules sequestered inside cells
- Phosphatidylserine recognized by several ligands
- Cells bleb in later phases of apoptosis
- Late apoptotic cells recognized by several ligands
- Abnormalities in adaptor molecules linked to SLE
- PS-receptor is nuclear protein
- Summary - the clearance of apoptotic cells
- Repulsion activity with CD31
- Putative model of phagocyte attraction
- iPLA-2 induces the release of LPC
- Model of caspase and iPLA-2
- Oxydative stress cause oxydation of phospholipids
- Anti-inflammatory effects of apoptotic cells
- Anti-inflammatory effect on monocytes with LPS
- AxV skews cytokine secretion
- Blocking clearance restores Ig response
- Balance of inflamation - bacteria and viruses
- Balance of inflamation - early apoptotic cells
- Balance of inflamation - late apoptotic cells
- Systemic lupus erythematosus
- Example of patient with SLE
- Twin studies of SLE
- SLE clinical characteristics
- SLE etiology
- SLE pathology
- Apoptotic cells accumulation in cultured PBMC
- Clearance of apoptotic cells is impaired in MoMa
- Diseases with accumulation of apoptotic cells
- Apoptotic cell accumulation in germinal centers
- Uningested apoptotic nuclei in germinal center
- Germinal center sections with SLE
- Impaired clearance of apoptotic nuclei in SLE (1)
- Impaired clearance of apoptotic nuclei in SLE (2)
- Immune fluorescence images by CFM
- Germinal center of normal healthy donor
- Germinal center during somatic mutations
- Apoptotic remnants accumulate in macrophages
- Clearance failure in SLE patients
- Summmary - AC accumulation in germinal centers
- Apoptotic trash as an antigen
- Phagocytic defect and anti-dsDNA autoAb
- Binding specificity of 33.C9 variants
- 33.C9 Ab and anti-dsDNA activity
- IgG autoAb gained DNA reactivity
- Apoptotic cells in skin of patients with CLE
- Apoptotic cells in skin with CLE after UV exposure
- Graph of accumulation of apoptotic cells
- Humoral factors help clear apoptotic cells
- Summary of humoral factors
- Low clearance in stem cell-derived phagocytes
- Stem cells show proliferation in vitro V15.3.05 (1)
- Stem cells show proliferation in vitro V15.3.05 (2)
- Reduced uptake of IgG-coated beads V9.03
- Summary of stem cells-derived phagocytes
- Animal models for clearance deficiency
- Gene targeted mice with SLE-like symptoms
- Low apoptotic cell clearance is an SLE risk factor
- Supporting institutions
- Acknowledgements
Topics Covered
- Anti-inflammatory and immunosuppressive effects of apoptotic cells
- Autoimmune disease and clearance of dying cells
- Clearance deficiency of apoptotic cells
- Germinal centre tingible body macrophage deficiency
- Model for the generation of nuclear autoimmunity
- Annexin V as adjuvans for irradiated tumor cells
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Talk Citation
Herrmann, M. (2007, October 1). Apoptotic cell clearance deficiency [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 17, 2024, from https://doi.org/10.69645/FGOL4148.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Martin Herrmann has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.