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Printable Handouts
Navigable Slide Index
- Introduction
- Endothelium - one of the largest tissues in body
- Endothelium is an active tissue
- Endothelial cells (EC) heterogeneity (1)
- Endothelial cells (EC) heterogeneity (2)
- Endothelial cells activity
- Vasoregulation
- EC and coagulation
- Regulatory mechanisms - anti and procoagulant
- EC and fibrinolysis
- The leukocyte adhesion cascade
- EC and inflammation/innate immunity
- Triggering of the cell mediated immune responses
- Role of the endothelium in autoimmune diseases
- Endothelium and autoimmunity
- EC and immune responses
- Endothelium as a target
- EC as target: anti-EC antibodies (AECA)
- AutoAbs against ECs (AECA)
- Endothelial planted antigens recognized by AECA
- AECA and pro-inflammatory/coagulant phenotype
- AECA may induce an endothelial lysis
- AECA may induce an endothelial apoptosis
- EC as target: ANCA
- ANCA-associated vasculitis
- EC as target: systemic vasculitis
- Giant cell arteritis
- EC as target: immunocomplexes
- Immune complex-mediated vasculitis
- Endothelium in autoimmune atherosclerosis
- Atherosclerosis: response to injury hypothesis
- EC as target: atherosclerosis
- EC as player: atherosclerosis
- EC activation in autoimmune diseases
- Vasculopathy vs. vasculitis
- Endothelium and antiphospholipid syndrome (APS)
- Endothelium as a target for antiphospholipid (aPL)
- Activated ECs as players in APS
- APS: pathogenic mechanisms
- Possible receptors for bGlycoprotein I (bGPI)
- Endothelium and scleroderma (SSc)
- Role of vascular damage in SSc pathogenesis
- Markers of EC perturbation
- Circulating markers: von Willebrand factor
- Circulating markers: endothelin-1
- Circulating markers: TPA and PAI-1
- Circulating markers: soluble adhesion molecules
- Circulating markers: sTM
- Circulating ECs (CEC)
- Increased occurrence of CECs
- Brachial FMD (omeral artery)
Topics Covered
- Physiological functions of the endothelium
- Endothelium as a target and player of immune responses
- Endothelium in autoimmune vasculitis and vasculopathies
- Anti-endothelial cell antibodies
- Anti-phospholipid syndrome
- Scleroderma
- Markers of endothelial perturbation
Talk Citation
Meroni, P.L. (2007, October 1). Endothelium and autoimmunity [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 17, 2024, from https://doi.org/10.69645/MAZW2886.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Pier Luigi Meroni has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.