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1. Introduction
2. Endothelium - one of the largest tissues in body
3. Endothelium is an active tissue
4. Endothelial cells (EC) heterogeneity (1)
5. Endothelial cells (EC) heterogeneity (2)
6. Endothelial cells activity
7. Vasoregulation
8. EC and coagulation
9. Regulatory mechanisms - anti and procoagulant
10. EC and fibrinolysis
11. The leukocyte adhesion cascade
12. EC and inflammation/innate immunity
13. Triggering of the cell mediated immune responses
14. Role of the endothelium in autoimmune diseases
15. Endothelium and autoimmunity
16. EC and immune responses
17. Endothelium as a target
18. EC as target: anti-EC antibodies (AECA)
19. AutoAbs against ECs (AECA)
20. Endothelial planted antigens recognized by AECA
21. AECA and pro-inflammatory/coagulant phenotype
22. AECA may induce an endothelial lysis
23. AECA may induce an endothelial apoptosis
24. EC as target: ANCA
25. ANCA-associated vasculitis
26. EC as target: systemic vasculitis
27. Giant cell arteritis
28. EC as target: immunocomplexes
29. Immune complex-mediated vasculitis
30. Endothelium in autoimmune atherosclerosis
31. Atherosclerosis: response to injury hypothesis
32. EC as target: atherosclerosis
33. EC as player: atherosclerosis
34. EC activation in autoimmune diseases
35. Vasculopathy vs. vasculitis
36. Endothelium and antiphospholipid syndrome (APS)
37. Endothelium as a target for antiphospholipid (aPL)
38. Activated ECs as players in APS
39. APS: pathogenic mechanisms
40. Possible receptors for bGlycoprotein I (bGPI)
41. Endothelium and scleroderma (SSc)
42. Role of vascular damage in SSc pathogenesis
43. Markers of EC perturbation
44. Circulating markers: von Willebrand factor
45. Circulating markers: endothelin-1
46. Circulating markers: TPA and PAI-1
47. Circulating markers: soluble adhesion molecules
48. Circulating markers: sTM
49. Circulating ECs (CEC)
50. Increased occurrence of CECs
51. Brachial FMD (omeral artery)

Topics Covered

• Physiological functions of the endothelium
• Endothelium as a target and player of immune responses
• Endothelium in autoimmune vasculitis and vasculopathies
• Anti-endothelial cell antibodies
• Anti-phospholipid syndrome
• Scleroderma
• Markers of endothelial perturbation

Links

Series:

• Autoimmunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on October 1, 2007

Financial Disclosures

• Prof. Pier Luigi Meroni has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.