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Printable Handouts
Navigable Slide Index
- Introduction
- What is autoimmunity?
- Female dominance in most autoimmune diseases
- Concept of tolerance
- Central tolerance
- Peripheral tolerance (1)
- Peripheral tolerance (2)
- Breakdown of tolerance
- What is needed for autoimmunity to occur?
- Autoimmune diseases (1)
- Autoimmune diseases (2)
- Susceptibility to autoimmune diseases
- Infection and initiation of autoimmunity (1)
- Initiation by bacterial infection
- Infection and initiation of autoimmunity (2)
- Initiation by viruses
- Infection and initiation of autoimmunity (3)
- Examples of important autoimmune diseases (1)
- Temporal arteritis
- Examples of important autoimmune diseases (2)
- Systemic lupus erythematosus (SLE)
- Risk of cardiovascular disease (CVD) in SLE
- Nested case control design
- Risk factors of CVD in SLE
- Examples of important autoimmune diseases (3)
- Atherosclerosis
- Atherosclerosis is an inflammatory disease
- Pro-inflammatory cytokines in atherosclerosis
- Plaque rupture leads to thrombosis
- The immune system in atherosclerosis (1)
- Heat shoch proteins
- Heat shock proteins (HSP) and atherosclerosis
- The immune system in atherosclerosis (2)
- Modification of LDL
- PAF and PAF-like lipids
- Oxidized LDL
- The immune system in atherosclerosis (3)
- Phosphorylcholine: epitope in OxLDL
- ELSA study design
- Study results
- Immunological differences between sexes
- Potential mechanisms for protective effects of aPC
- The immune system in atherosclerosis (4)
- Anti-phospholipid (aPL) antibodies
- Annexin A5
- Role of annexin-A5 in SLE-related CVDs (1)
- Role of annexin-A5 in SLE-related CVDs (2)
- Effect of IVIG on annexin A5 binding (1)
- Effect of IVIG on annexin A5 binding (2)
- Monoclonal aPL Ab inhibits annexin A5 binding
- How can aPL antibodies cause disease?
- Lupus anticoagulants
- Summary and conclusions
- Acknowledments
Topics Covered
- Autoimmunity
- High risk of atherosclerosis in autoimmune diseases, especially systemic lupus erythematosus (SLE)
- Antiphospholipid antibodies and atherosclerosis
- Association and risk factors for atherosclerosis and cardiovascular disease in SLE
- Autoimmune mechanisms in atherosclerosis in general
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Talk Citation
Frostegard, J. (2007, October 1). Autoimmunity and atherosclerosis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 15, 2024, from https://doi.org/10.69645/XGWW2685.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Johan Frostegard has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.