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1. Introduction
2. Outline
3. What is innate immunity? (1)
4. Critical role of innate immunity in children (1)
5. Critical role of innate immunity in children (2)
6. Elements of the immune system (1)
7. Elements of the immune system (2)
8. Defect in nonspecific immunity
9. Defect in adaptive immunity
10. Elements of the innate immune system
11. The cellular and humoral arms
12. Cellular elements for innate defense
13. Functions of the phagocytic system
14. Humoral arm of the innate immune system
15. Complement in innate defense
16. Complement cascade
17. Opsonization
18. Complement-mediated lysis
19. Inflammation: a fine balance
20. The canonical NFkappa-B pathway
21. Innate immunity -- sensing and signaling
22. NF-kappa-B structure
23. Defects that cause immunodeficiency in children
24. Inflammatory dysfunction
25. Child with IRAK-4 deficiency
26. IRAK-4 deficient macrophage response to LPS
27. Phenotype of IRAK-4 deficiency
28. STAT-1 deficiency
29. UNC-93B deficiency
30. IL-12 / interferon-gamma axis defect
31. Phagocytes in innate defense
32. Phagocytosis
33. Leukocyte adhesion deficiency
34. Lesions in LAD patient
35. LAD patient at one year of age
36. Chronic granulomatous disease
37. Molecular defects in CGD
38. Manifestations of CGD
39. Patient with mild CGD
40. Patient with severe CGD
41. Genetic polymorphisms and the innate immunity
42. Therapeutic approaches
43. Strategies to enhance/arm innate immune system
44. Conclusions

Topics Covered

• Host defense in children is composed of non-specific, innate and adaptive limbs
• Innate immunity is critical in defense against infection in children
• Innate immunity is composed of cellular and humoral elements
• Defects in innate immunity provide powerful insights into the importance of this limb of the host defense system in defense against infection
• New therapeutic strategies are being developed based upon novel observations of innate immunodeficiencies in children

Links

Series:

• Innate Immunity

Categories:

• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Publication History

• Published on May 31, 2009

Financial Disclosures

• Prof. David Speert has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.