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Printable Handouts
Navigable Slide Index
- Introduction
- Control of cell proliferation
- The budding yeast: Saccharomyces cerevisiae
- Why yeast?
- The budding yeast life cycle
- Placement of START in the cell cycle
- Observing START
- The concept of "START" - The G1 checkpoint
- Genetic characterization of START
- Interdependency of Cdk1 with START regulators
- Cyclin-dependent protein kinase (CDK)
- The cyclin/CDK cycle
- G1 cyclin/CDK is essential for START
- The role of CDK in START
- Periodic expression of Far1 and cyclins
- Cell cycle regulators accumulation in G1
- The molecular correlate of START
- G1-specific transcription
- Phosphorylation of Whi5 by Cln3
- Repression of MBF and SBF as cells exit G1
- Conservation of G1-specific transcription regulators
- G1-specific gene expression and human cancer
- The molecular determinant of START - summary
- Physiological regulators of START
- Mating generates diploid cells from haploid cells
- Cells of opposite mating types can conjugate
- Responses elicit by mating pheromone cascade
- Mating pheromone signaling pathway
- Far1 activation by mating pheromones
- Regulation of START by other stimuli
- Control of START by cell size
- The molecular basis for the Sizer and Timer
- Possible signals for achieving minimum cell size
- Summary
- Related reading
Topics Covered
- Control of cell proliferation
- The budding yeast: Saccharomyces cerevisiae
- Why yeast?
- The budding yeast life cycle
- Placement of START in the cell cycle
- Observing START
- The G1 Checkpoint
- Genetic characterization of START
- Interdependency of Cdk1 with other regulators of START
- Cyclin-Dependent Protein Kinase (CDK)
- The cyclin/CDK cycle
- G1 cyclin/CDK is essential for START
- The role of CDK in START
- Cell cycle dependent expression of Far1 and cyclins
- Periodic accumulation of yeast cell cycle regulators
- The molecular correlate of START
- G1-specific transcription
- G1-specific gene expression and human cancer
- The molecular determinant of START
- Physiological regulators of START
- Mating generates diploid cells from two haploid cells
- Cells of opposite mating types can conjugate
- Stimulation of the mating pheromone cascade elicits three primary responses
- Mating pheromone signaling pathway
- Mating pheromone promotes G1 phase arrest by activating the Cln/CDK inhibitor, Far1
- Regulation of START by other stimuli
- Control of START by cell size
- The molecular basis for the sizer and timer
- What is the signal for achievement of minimum cell size?
Talk Citation
Wittenberg, C. (2009, April 30). START control in yeast [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved August 24, 2024, from https://doi.org/10.69645/ITQB4117.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Curt Wittenberg has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.