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Printable Handouts
Navigable Slide Index
- Introduction
- How do cells form tissues
- From animal to molecule
- Differential adhesion is key
- Cell adhesion is key
- Epithelial architecture
- Adherens junctions mediate cell adhesion
- The cadherin-catenin complex
- Studying the process in the fruit fly
- Cell adhesion is essential
- Gastrulation illustrates the morphogenesis process
- Without adhesion gastrulation fails
- Metastasis requires loss of adhesion
- Changing the existing model of adhesion
- The dynamic events in embryogenesis
- Abl kinase and leukemia
- Abl tyrosine kinase in Drosophila
- Model of Abl in the CNS
- Abl in morphogenesis
- Dorsal closure
- Researcher Lizz Grevengoed
- Abl's role in morphogenesis
- Abl and cell shape change
- Ena is a key target of Abl in morphogenesis
- Ena and Arm co-localize at adherens junctions
- Abl regulates apical actin polymerization
- How does Abl function during complex events?
- Researcher Don Fox
- Neural tube and ventral furrow
- Apical cell constriction
- Apical constriction in action
- Wild-type ventral furrow
- Abl is required for coordinated apical constriction
- Embryos lacking functional Abl
- Models of mesoderm invagination
- Other criticl actin regulators
- Ena/VASP proteins
- Researcher Julie Gates
- The dorsal closure process
- Lammelipodia and filopodia
- Wild-type cell protrusions
- Ena and filopodia
- Ena has a key role in the formation of filopodia
- Apical-basal polarity of epithelia
- Researcher Tony Harris
- Primary landmarks of polarity
- Yeast budding as an example
- C. elegans one cell polarity
- Establishment of epithelial polarity
- AJs as primary landmarks for epithelial polarity
- Without AJs epithelial polarity is lost
- AJs as landmarks for establishing polarity
- Complex interactions among polarity determinants
- The initial establishment of polarity
- Advantages of Drosophila
- Are AJs the primary landmark?
- Baz is upstream of AJs
- Baz is normally localized in AJ mutants
- Ajs are mislocalized in baz mutants
- How is Baz positioned?
- Dynein-mediated transport
- Dynein is required for Baz positioning
- Baz/PAR3, PAR6 and aPKC
- PAR6 and aPKC apical to Baz and cadherin
- Revised model for polarity and remaining questions
- Thank you
- References
Topics Covered
- Self-assembly of cells into tissues and organs
- Understanding this process from the molecular to whole animal level
- Different cell types
- Cell adhesion
- Epithelial sheets
- Drosophila cell adhesion
- Gastrulation
- Cadherin expression
- Normal cell behavior and human disease
- Abelson tyrosine kinase
- Ena and Abl
- How does Abl function during more complex events of morphogenesis
- Other actin regulators
- Dorsal closure
- Cells use 'landmarks' to establish and elaborate polarity
- Adherens junctions
- Drosophila cellularization
- Bazooka
Talk Citation
Peifer, M. (2008, September 29). The miracle of morphogenesis, cell adhesion, polarity and cytoskeletal regulation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 25, 2018, from https://hstalks.com/bs/974/.Talk Information
The miracle of morphogenesis, cell adhesion, polarity and cytoskeletal regulation
Published on September 29, 2008
43 min
Other Talks in the Series: The Legacy of Drosophila Genetics
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