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1. Introduction
2. How do cells form tissues
3. From animal to molecule
4. Differential adhesion is key
5. Cell adhesion is key
6. Epithelial architecture
7. Adherens junctions mediate cell adhesion
8. The cadherin-catenin complex
9. Studying the process in the fruit fly
10. Cell adhesion is essential
11. Gastrulation illustrates the morphogenesis process
12. Without adhesion gastrulation fails
13. Metastasis requires loss of adhesion
14. Changing the existing model of adhesion
15. The dynamic events in embryogenesis
16. Abl kinase and leukemia
17. Abl tyrosine kinase in Drosophila
18. Model of Abl in the CNS
19. Abl in morphogenesis
20. Dorsal closure
21. Researcher Lizz Grevengoed
22. Abl's role in morphogenesis
23. Abl and cell shape change
24. Ena is a key target of Abl in morphogenesis
25. Ena and Arm co-localize at adherens junctions
26. Abl regulates apical actin polymerization
27. How does Abl function during complex events?
28. Researcher Don Fox
29. Neural tube and ventral furrow
30. Apical cell constriction
31. Apical constriction in action
32. Wild-type ventral furrow
33. Abl is required for coordinated apical constriction
34. Embryos lacking functional Abl
35. Models of mesoderm invagination
36. Other criticl actin regulators
37. Ena/VASP proteins
38. Researcher Julie Gates
39. The dorsal closure process
40. Lammelipodia and filopodia
41. Wild-type cell protrusions
42. Ena and filopodia
43. Ena has a key role in the formation of filopodia
44. Apical-basal polarity of epithelia
45. Researcher Tony Harris
46. Primary landmarks of polarity
47. Yeast budding as an example
48. C. elegans one cell polarity
49. Establishment of epithelial polarity
50. AJs as primary landmarks for epithelial polarity
51. Without AJs epithelial polarity is lost
52. AJs as landmarks for establishing polarity
53. Complex interactions among polarity determinants
54. The initial establishment of polarity
55. Advantages of Drosophila
56. Are AJs the primary landmark?
57. Baz is upstream of AJs
58. Baz is normally localized in AJ mutants
59. Ajs are mislocalized in baz mutants
60. How is Baz positioned?
61. Dynein-mediated transport
62. Dynein is required for Baz positioning
63. Baz/PAR3, PAR6 and aPKC
64. PAR6 and aPKC apical to Baz and cadherin
65. Revised model for polarity and remaining questions
66. Thank you
67. References

Topics Covered

• Self-assembly of cells into tissues and organs
• Understanding this process from the molecular to whole animal level
• Different cell types
• Cell adhesion
• Epithelial sheets
• Drosophila cell adhesion
• Gastrulation
• Cadherin expression
• Normal cell behavior and human disease
• Abelson tyrosine kinase
• Ena and Abl
• How does Abl function during more complex events of morphogenesis
• Other actin regulators
• Dorsal closure
• Cells use 'landmarks' to establish and elaborate polarity
• Adherens junctions
• Drosophila cellularization
• Bazooka

Links

Series:

• The Legacy of Drosophila Genetics

Categories:

• Cell Biology
• Reproduction & Development

Talk Citation

Peifer, M. (2008, September 29). The miracle of morphogenesis, cell adhesion, polarity and cytoskeletal regulation [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved January 18, 2020, from https://hstalks.com/bs/974/.

Publication History

• Published on September 29, 2008
• Reviewed on May 31, 2018

Financial Disclosures

• Prof. Mark Peifer has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.