• Introduction
• 63 min
  1. Drosophila genetics - the first 25 years

  • Prof. Dan Lindsley
• Establishment of the Primary Body Axes
• 28 min
  2. Homeotic genes in Drosophila's bithorax complex - The legacy of Ed Lewis

  • Prof. Francois Karch
• 30 min
  3. Limb development: how Drosophila genetics can be used to understand pattern formation

  • Prof. Konrad Basler
• Cell Type Specification and Organ Systems
• 63 min
  4. From germ cell specification to gonad formation

  • Prof. Ruth Lehmann
• 37 min
  5. Drosophila stem cells

  • Prof. Michael Buszczak
• 46 min
  6. Legacy of drosophila genetics: female germline stem cells

  • Prof. Michael Buszczak
• 34 min
  7. Intestinal stem cell-mediated repair in Drosophila 1

  • Prof. Tony Ip
• 30 min
  8. Intestinal stem cell-mediated repair in Drosophila 2

  • Prof. Tony Ip
• 43 min
  9. The miracle of morphogenesis, cell adhesion, polarity and cytoskeletal regulation

  • Prof. Mark Peifer
• 34 min
  10. Axon guidance in Drosophila

  • Prof. John Thomas
• 35 min
  11. Development and physiology of the heart

  • Prof. Rolf Bodmer
• 37 min
  12. Identification of host defenses in the Drosophila gut using genome-scale RNAi

  • Prof. Dominique Ferrandon
• Genome Organization and Function
• 53 min
  13. The genetic analysis of meiosis in Drosophila melanogaster females

  • Prof. R. Scott Hawley
• 46 min
  14. Genome scale analysis of cellular processes using RNAi

  • Dr. Amy Kiger
• 36 min
  15. Dorsal-ventral patterning of the Drosophila embryo

  • Prof. Mike Levine
• 34 min
  16. Bone morphogenetic protein (BMP) signaling in drosophila: from germline to early embryogenesis

  • Dr. Helena Araujo
• 27 min
  17. Genome-wide pooled CRISPR screen in arthropod cells

  • Prof. Norbert Perrimon
• Behavior
• 40 min
  18. The development of the peripheral nervous system in the fruitfly Drosophila

  • Prof. Hugo Bellen
• 54 min
  19. Genetics of chemosensory transduction: taste and smell

  • Dr. Leslie Vosshall
• 72 min
  20. Cracking the case of circadian rhythms by Drosophila genetics

  • Prof. Jeffrey C. Hall
• 46 min
  21. Sleep in Drosophila

  • Dr. Ralph Greenspan
• 91 min
  22. Drosophila's contribution to the genetics of learning and memory

  • Prof. Tim Tully
• 34 min
  23. Drosophila as a model for drug addiction

  • Prof. Ulrike Heberlein
• Mechanism of Human Disease
• 65 min
  24. Cross-genomic analysis of human disease genes

  • Prof. Ethan Bier
• 56 min
  25. Human neurodegenerative disease: insights from Drosophila genetics

  • Prof. Nancy Bonini
• 21 min
  26. Metastasis of Drosophila tumors

  • Prof. Allen Shearn
• 
  27. Rac-enhanced CAR immunotherapy: RaceCAR

  • Prof. Denise Montell
• 34 min
  28. Control of tissue growth: elucidation of the Hippo signaling pathway

  • Dr. Duojia Pan
• Evolution of Adaptive Novelties
• 56 min
  29. The evolution of morphological novelty

  • Prof. Nipam Patel
• 36 min
  30. The genetic architecture of complex traits: lessons from Drosophila

  • Prof. Trudy Mackay
• Archived Lectures *These may not cover the latest advances in the field
• 25 min
  31. Using gene expression information to provide insights into patterning and differentiation

  • Prof. Angelike Stathopoulos
• 49 min
  32. Regulation of gastrulation in Drosophila

  • Prof. Dr. Maria Leptin
• 31 min
  33. microRNA function in stem cells

  • Prof. Hannele Ruohola-Baker

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Transcription factors in developmental hierarchies
3. Creation of three germ layers during gastrulation
4. Cell shape changes during gastrulation
5. Drosophila embryo gastrulation process
6. Genetic cascade regulating mesoderm creation
7. Twist is required for mesoderm development
8. Maternal factors in the epithelial cells
9. Zygotic factors in the epithelial cells
10. Early twist target genes and their functions
11. The snail target gene
12. The fog target gene
13. The string (cdc25) target gene
14. The FGF-R and dof adapter target genes
15. Snail and Fog are needed for invagination
16. Twist targets involved in ventral furrow formation
17. Twist targets
18. Gastrulation defects in embryos
19. Genes uncovered by the deficiencies
20. Mitotic domains
21. String/cdc25 expression is the limiting factor
22. The first domain to express String
23. Prospective mesoderm is the tenth to divide
24. Premature mitoses in mutant embryos
25. Is premature mitosis a cause or a result?
26. Results of suppressing premature mitoses
27. Tribbles mutants are viable
28. Df(3R)Tl-P target gene
29. Df(3R)Tl-P function
30. T48 is a twist target
31. T48 structure
32. Membrane localisation of T48 in epithelium
33. T48 has a potential PDZ binding motif
34. PDZ domain
35. Potential interactors for t48
36. RhoGEF necessary for myosin apical localisation
37. T48 binds to RhoGEF2
38. Testing for binding in S2 Schneider cells
39. T48 recruits RhoGEF2 to the plasma membrane
40. Do T48 and RhoGEF2 interact in the embryo?
41. RhoGEF and Armadillo in a bit older embryo
42. RhoGEF and Armadillo a few minutes later
43. Armadillo and rhoGEF in t48 mutants
44. T48 mutants have a mild phenotype and are viable
45. Gastrulation fails if both t48 and Fog are lost
46. Armadillo and rhoGEF in cta t48 double mutants
47. How does it all fit together?
48. Microtubule plus end associated rhoGEF
49. Effect of t48 and Fog on gastrulation process
50. Snail down regulates adherence junctions
51. RhoGEF and armadillo in snail mutants
52. Overview diagram I
53. Tribolium castaneum gastrulation
54. Acknowledgements

Topics Covered

• Events during gastrulation and mesoderm cell invagination
• Cell shape changes
• Genes acting upstream of mesodermal invagination
• Search for genes controlling mesoderm cell shape changes
• The role of cell division
• The importance of apical concentration of cytoskeletal regulators, and proteins mediating their apical concentration

Links

Series:

• The Legacy of Drosophila Genetics

Categories:

• Reproduction & Development

Talk Citation

Publication History

• Published on September 29, 2008
• Archived on February 25, 2021

Financial Disclosures

• Prof. Dr. Maria Leptin has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.