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- Introduction
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1. Prions and amyloids: introduction
- Prof. Reed Wickner
- Mammalian Prions
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2. Transgenic mouse models of prion diseases
- Prof. Glenn Telling
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3. Mechanism of prion generation in vitro
- Dr. Surachai Supattapone
- Non-Prion Amyloids
- Yeast Prions
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6. Chaperones and prions
- Prof. Yury Chernoff
- Beneficial Amyloids
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7. The dark side of amyloid: PMEL, a natural amyloid in melanosome biogenesis
- Prof. Michael Marks
- Archived Lectures *These may not cover the latest advances in the field
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8. Predicting TSE transmission
- Prof. Jean Manson
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10. Yeast and fungal prions: a help or a hindrance?
- Prof. Reed Wickner
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11. [PIN+]: prions beget prions
- Prof. Susan Liebman
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12. Yeast prions and protein chaperones
- Dr. Daniel Masison
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13. Mechanisms of yeast prion propagation
- Prof. Mick Tuite
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14. Propagation and variability of the yeast [PSI+] prion
- Prof. Michael Ter-Avanesyan
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15. The genetics and biology of the [Het-s] prion of Podospora
- Prof. Sven Saupe
Printable Handouts
Navigable Slide Index
- Introduction
- Pathology of diseases
- Prion diseases
- The first family with a prion mutation
- Variant Creutzfeldt-Jakob disease
- Sporadic Creutzfeldt-Jakob disease
- Prion disease conclusions
- Alzheimer's disease
- Cleavage of APP by presenilin-1
- Metabolism of APP
- APP mutations associated with disease
- 7Mb duplication of locus around APP
- APP locus and "sporadic" Alzheimer's disease
- Conclusion on Alzheimer's disease
- Diseases with only Lewy bodies
- Alpha-synuclein and Parkinson's disease
- Iowa kindred structure
- Alpha-synuclein locus triplication
- Sporadic Parkinson's disease
- Lewy bodies disease conclusions
- Disease with only tau pathology
- Tau mutations associated with disease
- The microtubule associated protein tau
- Mutations in Tau exon 10 3' splice site
- Evolution of human tau haplotypes
- Tau gene and progressive supernuclear palsy
- Tagging SNPs selection
- More complex than Just H1/H2
- Association with PSP is driven by H1c allele
- H1c has about 10% increased overall expression
- H1c has about 20% increased exon 10 expression
- Primary tauopathies
- Overall conclusions
- "Prion-like" behaviour of A-beta
- Seeding of beta-amyloidosis in primates
- Possible meaning of the "spreading" of diseases
- Spread of Alzheimer's disease
- Spread of Parkinson's disease
- MAPT and alpha-synuclein in extracellular fluides?
- Possibility for a general mechanism
Topics Covered
- Pathology of diseases
- Prion diseases
- The first family with a prion mutation: Creutzfeldt-Jacob disease
- Alzheimer's disease
- 7Mb duplication of locus around APP
- APP probably a locus for "sporadic" Alzheimer's disease
- Diseases with only Lewy bodies: Parkinson's disease and Lewy body dementia
- Iowa kindred structure
- alpha-synuclein
- Diseases with only Tau pathology
- The microtubule associated protein tau
- Evolution of human tau haplotypes
- Tagging SNPs selection
- More complex than just H1/H2
- Association with PSP is driven by H1c allele
- Primary tauopathies
- "Prion-like " behaviour of A-beta
- Does the "spreading" of diseases reflect a less extreme version of infection?
- Alzheimer's disease is a neuroanatomical disease which "spreads"
- Parkinson's disease pathology also seems to spread
- MAPT and alpha-synuclein in the extracellular compartment?
Links
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Talk Citation
Hardy, J. (2008, September 4). Similarities between prion diseases and other neurodegenerative diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved March 31, 2023, from https://hstalks.com/bs/956/.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. John Hardy, Consultant: Eisai Speaker's Bureau: Eli Lily Grant/Research Support (Principal Investiqator): MRC/Wellcome Trust
Similarities between prion diseases and other neurodegenerative diseases
Published on September 4, 2008
48 min
A selection of talks on Neuroscience
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