• Introduction
• 30 min
  1. Prions and amyloids: introduction

  • Prof. Reed Wickner
• Mammalian Prions
• 26 min
  2. Transgenic mouse models of prion diseases

  • Prof. Glenn Telling
• 31 min
  3. Mechanism of prion generation in vitro

  • Dr. Surachai Supattapone
• Non-Prion Amyloids
• 48 min
  4. Similarities between prion diseases and other neurodegenerative diseases

  • Prof. John Hardy
• 43 min
  5. Molecular structure of amyloid and prion fibrils: insights from solid state NMR

  • Dr. Robert Tycko
• Yeast Prions
• 42 min
  6. Chaperones and prions

  • Prof. Yury Chernoff
• Beneficial Amyloids
• 52 min
  7. The dark side of amyloid: PMEL, a natural amyloid in melanosome biogenesis

  • Prof. Michael Marks
• Archived Lectures *These may not cover the latest advances in the field
• 41 min
  8. Predicting TSE transmission

  • Prof. Jean Manson
• 53 min
  9. Generation and propagation of infectious prions by cyclic amplification of protein misfolding

  • Prof. Claudio Soto
• 30 min
  10. Yeast and fungal prions: a help or a hindrance?

  • Prof. Reed Wickner
• 42 min
  11. [PIN+]: prions beget prions

  • Prof. Susan Liebman
• 36 min
  12. Yeast prions and protein chaperones

  • Dr. Daniel Masison
• 54 min
  13. Mechanisms of yeast prion propagation

  • Prof. Mick Tuite
• 31 min
  14. Propagation and variability of the yeast [PSI+] prion

  • Prof. Michael Ter-Avanesyan
• 43 min
  15. The genetics and biology of the [Het-s] prion of Podospora

  • Prof. Sven Saupe
• 33 min
  16. The structure of amyloid fibrils of the HET-s (218-289) prion as seen by solid-state NMR

  • Prof. Beat Meier

Printable Handouts

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Navigable Slide Index

1. Introduction
2. Pathology of diseases
3. Prion diseases
4. The first family with a prion mutation
5. Variant Creutzfeldt-Jakob disease
6. Sporadic Creutzfeldt-Jakob disease
7. Prion disease conclusions
8. Alzheimer's disease
9. Cleavage of APP by presenilin-1
10. Metabolism of APP
11. APP mutations associated with disease
12. 7Mb duplication of locus around APP
13. APP locus and "sporadic" Alzheimer's disease
14. Conclusion on Alzheimer's disease
15. Diseases with only Lewy bodies
16. Alpha-synuclein and Parkinson's disease
17. Iowa kindred structure
18. Alpha-synuclein locus triplication
19. Sporadic Parkinson's disease
20. Lewy bodies disease conclusions
21. Disease with only tau pathology
22. Tau mutations associated with disease
23. The microtubule associated protein tau
24. Mutations in Tau exon 10 3' splice site
25. Evolution of human tau haplotypes
26. Tau gene and progressive supernuclear palsy
27. Tagging SNPs selection
28. More complex than Just H1/H2
29. Association with PSP is driven by H1c allele
30. H1c has about 10% increased overall expression
31. H1c has about 20% increased exon 10 expression
32. Primary tauopathies
33. Overall conclusions
34. "Prion-like" behaviour of A-beta
35. Seeding of beta-amyloidosis in primates
36. Possible meaning of the "spreading" of diseases
37. Spread of Alzheimer's disease
38. Spread of Parkinson's disease
39. MAPT and alpha-synuclein in extracellular fluides?
40. Possibility for a general mechanism

Topics Covered

• Pathology of diseases
• Prion diseases
• The first family with a prion mutation: Creutzfeldt-Jacob disease
• Alzheimer's disease
• 7Mb duplication of locus around APP
• APP probably a locus for "sporadic" Alzheimer's disease
• Diseases with only Lewy bodies: Parkinson's disease and Lewy body dementia
• Iowa kindred structure
• alpha-synuclein
• Diseases with only Tau pathology
• The microtubule associated protein tau
• Evolution of human tau haplotypes
• Tagging SNPs selection
• More complex than just H1/H2
• Association with PSP is driven by H1c allele
• Primary tauopathies
• "Prion-like " behaviour of A-beta
• Does the "spreading" of diseases reflect a less extreme version of infection?
• Alzheimer's disease is a neuroanatomical disease which "spreads"
• Parkinson's disease pathology also seems to spread
• MAPT and alpha-synuclein in the extracellular compartment?

Links

Series:

• Prions and Amyloids

Categories:

• Biochemistry
• Cell Biology
• Clinical Practice
• Neuroscience

Therapeutic Areas:

• Neurology

Talk Citation

Publication History

• Published on September 4, 2008

Financial Disclosures

• Prof. John Hardy, Consultant: Eisai Speaker's Bureau: Eli Lily Grant/Research Support (Principal Investiqator): MRC/Wellcome Trust