On Sunday, April 20th 2025, starting 8:30am GMT, there will be maintenance work that will involve the website being unavailable during parts of the day. We apologize for any inconvenience this may cause and appreciate your understanding.
We noted you are experiencing viewing problems
-
Check with your IT department that JWPlatform, JWPlayer and Amazon AWS & CloudFront are not being blocked by your network. The relevant domains are *.jwplatform.com, *.jwpsrv.com, *.jwpcdn.com, jwpltx.com, jwpsrv.a.ssl.fastly.net, *.amazonaws.com and *.cloudfront.net. The relevant ports are 80 and 443.
-
Check the following talk links to see which ones work correctly:
Auto Mode
HTTP Progressive Download Send us your results from the above test links at access@hstalks.com and we will contact you with further advice on troubleshooting your viewing problems. -
No luck yet? More tips for troubleshooting viewing issues
-
Contact HST Support access@hstalks.com
-
Please review our troubleshooting guide for tips and advice on resolving your viewing problems.
-
For additional help, please don't hesitate to contact HST support access@hstalks.com
We hope you have enjoyed this limited-length demo
This is a limited length demo talk; you may
login or
review methods of
obtaining more access.
Printable Handouts
Navigable Slide Index
- Introduction
- Pathology of diseases
- Prion diseases
- The first family with a prion mutation
- Variant Creutzfeldt-Jakob disease
- Sporadic Creutzfeldt-Jakob disease
- Prion disease conclusions
- Alzheimer's disease
- Cleavage of APP by presenilin-1
- Metabolism of APP
- APP mutations associated with disease
- 7Mb duplication of locus around APP
- APP locus and "sporadic" Alzheimer's disease
- Conclusion on Alzheimer's disease
- Diseases with only Lewy bodies
- Alpha-synuclein and Parkinson's disease
- Iowa kindred structure
- Alpha-synuclein locus triplication
- Sporadic Parkinson's disease
- Lewy bodies disease conclusions
- Disease with only tau pathology
- Tau mutations associated with disease
- The microtubule associated protein tau
- Mutations in Tau exon 10 3' splice site
- Evolution of human tau haplotypes
- Tau gene and progressive supernuclear palsy
- Tagging SNPs selection
- More complex than Just H1/H2
- Association with PSP is driven by H1c allele
- H1c has about 10% increased overall expression
- H1c has about 20% increased exon 10 expression
- Primary tauopathies
- Overall conclusions
- "Prion-like" behaviour of A-beta
- Seeding of beta-amyloidosis in primates
- Possible meaning of the "spreading" of diseases
- Spread of Alzheimer's disease
- Spread of Parkinson's disease
- MAPT and alpha-synuclein in extracellular fluides?
- Possibility for a general mechanism
Topics Covered
- Pathology of diseases
- Prion diseases
- The first family with a prion mutation: Creutzfeldt-Jacob disease
- Alzheimer's disease
- 7Mb duplication of locus around APP
- APP probably a locus for "sporadic" Alzheimer's disease
- Diseases with only Lewy bodies: Parkinson's disease and Lewy body dementia
- Iowa kindred structure
- alpha-synuclein
- Diseases with only Tau pathology
- The microtubule associated protein tau
- Evolution of human tau haplotypes
- Tagging SNPs selection
- More complex than just H1/H2
- Association with PSP is driven by H1c allele
- Primary tauopathies
- "Prion-like " behaviour of A-beta
- Does the "spreading" of diseases reflect a less extreme version of infection?
- Alzheimer's disease is a neuroanatomical disease which "spreads"
- Parkinson's disease pathology also seems to spread
- MAPT and alpha-synuclein in the extracellular compartment?
Links
Series:
Categories:
Therapeutic Areas:
Talk Citation
Hardy, J. (2008, September 4). Similarities between prion diseases and other neurodegenerative diseases [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2025, from https://doi.org/10.69645/FLSL4474.Export Citation (RIS)
Publication History
- Published on September 4, 2008
Financial Disclosures
- Prof. John Hardy, Consultant: Eisai Speaker's Bureau: Eli Lily Grant/Research Support (Principal Investiqator): MRC/Wellcome Trust
Similarities between prion diseases and other neurodegenerative diseases
Published on September 4, 2008
48 min
A selection of talks on Clinical Practice
Hide