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Printable Handouts
Navigable Slide Index
- Introduction
- Ca is a key signaling molecule in the cell
- The revival of protein-based Ca probes
- Protein based fluorescent calcium probes: aequrin
- Protein based fluorescent calcium probes: GFP
- Ca accumulation in mitochondrial matrix (1)
- Ca accumulation in mitochondrial matrix ( 2)
- Ca diffusion through OMM: VDAC
- The VDAC repertoire is rate-limiting
- Mitochondrial Ca uptake in VDAC overexpression
- VDAC shortens the mitochondrial Ca uptake delay
- Ca transport across the inner membrane
- The basic principles of inner membrane transport
- Effect of membrane potential on Ca equilibrium
- What prevents mitochondrial Ca overload?
- Why is Ca uptake fast in stimulated cells?
- The mitochondrial calcium uniporter (mCU)
- The return of Ca to basal values
- Ca uptake and regulation of aerobic metabolism
- Luciferase: a gene-encoded ATP probe
- Ca can lead to an increased ATP production
- Ca increased and mitochondria ATP production
- Ca uptake and activation of apoptotic process
- Ca synergizes with apoptotic stimuli
- Ca signals reduction by Bcl-2
- Ca uptake and the apoptotic process
- HBx induces Ca mitochondrial rise
- Roles of mitochondrial Ca uptake: summery
- Modulation of [Ca] microdomains
- Pancreatic acinar cells: mitochondrial firewall
- Summary
Topics Covered
- Targeted Calcium indicators
- The principles of mitochondrial Calcium accumulation
- The role of the outer membrane channel VDAC
- The mitochondrial Calcium uniporter of the inner membrane (MCU)
- The ER-mitochondria contacts
- Calcium re-extrusion
- ATP measurements
- The role of Calcium in mitochondrial functions (aerobic metabolism and apoptosis induction)
Talk Citation
Rizzuto, R. (2007, October 1). Regulation and role of mitochondrial Ca2+ homeostasis [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved October 12, 2024, from https://doi.org/10.69645/LYSN8890.Export Citation (RIS)
Publication History
Financial Disclosures
- Prof. Rosario Rizzuto has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.