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1. Introduction
2. Scleroderma
3. Systemic sclerosis - epidemiology
4. Systemic sclerosis - tissue pathologies
5. Clinical manifestations of scleroderma
6. Scleroderma - pathology
7. SSc - vasculopathy and fibrosis
8. Arterial fibrosis - pathology
9. SSc nailford capillary abnormalities
10. Evidence of genetic effects
11. Twin concordance
12. Prevalences in american indians
13. Choctaw nation of Oklahoma - location
14. Geneaology of SSc in the Choctaw
15. Pushmataha
16. Fibrillin - 1 gene (fbn1)
17. Genome scan for disease loci associated with SSC
18. Allelic distribution - cases and controls
19. Autoimmunity regions from genome scans
20. Autoimmunity genes
21. Gene mapping in scleroderma
22. MHC class 2 haplotypes
23. Protein tyrosine phosphatase 2 (PTPN22)
24. PTPN22 in scleroderma
25. Genetic associations in scleroderma
26. Uses for DNA microarrays
27. SSC - twin concordance
28. SSC fibroblast DNA microarrays
29. Microarray analyses
30. Dendrogram for clustering experiments
31. Genes clustered in SSc affected individuals
32. Twin concordance - fibroblast genes
33. Fibroblast microarray results imply genetic effect
34. SSc twin sera stimulate normal fibroblasts
35. SSc - occurrence and risk in families
36. Uses for DNA microarrays
37. Expression of SPARC gene
38. Increased SPARC expression in SSc fibroblasts
39. SPARC stain in fibroblasts after SPARC siRNA
40. Western blots of collagen type l and SPARC
41. Uses for DNA microarrays
42. Dendrogram for clustering experiments - blood cells
43. Microarrays of peripheral blood cells
44. Dendrogram for clustering experiments
45. Genes clustered in affected individuals
46. Interferon- related genes
47. Vasculotrophic genes
48. Immune function genes
49. On-line data sources
50. Acknowledgements
51. Support

Topics Covered

• The genetics of scleroderma
• What is the evidence that it is genetic?
• Familial aggregation and twin studies
• The use of large case-control studies to identify the genes
• The emerging genetic heterogeneity of the disease
• The use of genomic approaches to discover the molecular pathways contributing to this disease
• Using microarrays to better understand pathogenesis and to define prognosis

Links

Series:

• Gene-Environment Interactions

Categories:

• Clinical Practice
• Genetics & Epigenetics
• Immunology

Therapeutic Areas:

• Immunology & Inflammation

Talk Citation

Arnett, F. (2007, October 1). Indians, twins and scleroderma: genetic and genomic studies [Video file]. In The Biomedical & Life Sciences Collection, Henry Stewart Talks. Retrieved April 18, 2025, from https://doi.org/10.69645/EFKW9262.
Export Citation (RIS)

Publication History

• Published on October 1, 2007
• Archived on June 30, 2016

Financial Disclosures

• Prof. Frank Arnett has not informed HSTalks of any commercial/financial relationship that it is appropriate to disclose.